Advances in Targeted Delivery of Natural Flavonoids

Graphical abstract of the Research Topic. This figure was created using BioRender.com.

Editorial

24 August 2023

Editorial: Advances in targeted delivery of natural flavonoids

Yang Xu

Zhenquan Jia

and

Hongming Su

1,603 views

0 citations

Editors

Zhenquan Jia

Department of Biology, College of Arts and Sciences, University of North Carolina at Greensboro

Hongming Su

Department of Food Science and Nutrition, College of Food, Agricultural and Natural Resource Sciences, University of Minnesota Twin Cities

Yang Xu

Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University

Impact

Apigenin protected experimental UC in mice. (A) A schematic of the UC and apigenin (AP) treatment design. (B) Changes in body weights (g) of mice. (C) Disease activity index (DAI) scores for weight loss and fecal status in each group. (D) Spleen coefficient of each treatment group. **P < 0.01.

Original Research

16 December 2022

Apigenin remodels the gut microbiota to ameliorate ulcerative colitis

Rongrong Fu

, 6 more and

Min Zhang

Introduction: Ulcerative colitis (UC), a chronic non-specific colorectal inflammatory disease with unclear etiology, has long plagued human health. Gut microbiota dysbiosis destroy homeostasis of the colon, which is closely related to ulcerative colitis progress. Apigenin, a flavonoid widely present in celery, has been found to improve ulcerative colitis. However, the potential molecular mechanism of apigenin ameliorating ulcerative colitis through protecting intestinal barrier and regulating gut microbiota remains undefined.

Methods: Dextran sodium sulfate (DSS)-induced colitis mouse model was conducted to evaluate the effect of apigenin on UC. Disease activity index score of mice, colon tissue pathological, cytokines analysis, intestinal tight junction proteins expression, and colonic content short-chain fatty acids (SCFAs) and 16S rRNA gene sequencing were conducted to reflect the protection of apigenin on UC.

Results: The results indicated that apigenin significantly relieved the intestinal pathological injury, increased goblet cells quantity and mucin secretion, promoted anti-inflammatory cytokines IL-10 expression, and inhibited the expression of proinflammatory cytokines, TNF-α, IL-1β, IL-6 and MPO activity of colon tissue. Apigenin increased ZO-1, claudin-1 and occludin expressions to restore the integrity of the intestinal barrier. Moreover, apigenin remodeled the disordered gut microbiota by regulating the abundance of Akkermansia, Turicibacter, Klebsiella, Romboutsia, etc., and its metabolites (SCFAs), attenuating DSS-induced colon injury. We also investigated the effect of apigenin supplementation on potential metabolic pathways of gut microbiota.

Conclusion: Apigenin effectively ameliorated DSS-induced UC via balancing gut microbiome to inhibit inflammation and protect gut barrier. With low toxicity and high efficiency, apigenin might serve as a potential therapeutic strategy for the treatment of UC via regulating the interaction and mechanism between host and microorganism.

6,283 views

38 citations

Original Research

26 September 2022

Cellular uptake, transport mechanism and anti-inflammatory effect of cyanidin-3-glucoside nanoliposomes in Caco-2/RAW 264.7 co-culture model

Mengyu Yang

, 5 more and

Hao Zhong

To our knowledge, no feasible, valid and reliable instrument exists to examine tactical skills over the course of multiple training and game situations in tennis yet. Therefore, the aim of this study was to develop and evaluate the psychometric properties of the Tactical Skills Questionnaire in Tennis (TSQT). The TSQT is a new instrument with closed-ended questions designed to examine tactical skills in tennis players. Participants were 233 competitive tennis players (age: 17.06 ± 4.74 years) competing on national or regional levels. With a principal component analysis (PCA) we identified four theoretically meaningful subscales for the 31-item TSQT: “Anticipation and positioning,” “Game intelligence and adaptability,” “Decision-making,” and “Recognizing game situations” and confirmed them with a confirmatory factor analysis (CFA) (χ² = 527.02, df = 426, p < 0.001, CFI = 0.93, RMSEA = 0.045, SRMR = 0.079). Internal consistency was good, with Cronbach's alpha of 0.89 for the entire scale and McDonald's omega ranging from 0.69 to 0.78 for the separate subscales. A subsample of 57 players completed the TSQT twice to assess test-retest reliability. Absolute test-retest reliability of the subscales was good with no significant differences in mean scores between test and retest (p > 0.05). Relative test-retest reliability was moderate with ICC values ranging from 0.65 to 0.71. National players outperformed regional players on the subscales “Game intelligence and adaptability,” “Decision-making,” and “Recognizing game situations” (p < 0.05), and there was a trend toward significance for “Anticipation and positioning” (p = 0.07). This study supported the psychometric properties of the TSQT. Evaluating tactical skills with the TSQT provides players, coaches and other professionals with insight in players' self-assessed tactical skills over the course of multiple training and game situations. It creates the opportunity for players to reflect on their skills and detect personal development areas with their coach. We advise to use this information as input for tailor-made training programs.

5,488 views

23 citations

Original Research

24 August 2022

Cyanidin-3-O-glucoside extracted from the Chinese bayberry (Myrica rubra Sieb. et Zucc.) alleviates antibiotic-associated diarrhea by regulating gut microbiota and down-regulating inflammatory factors in NF-κB pathway

Yanshuai Wang

, 9 more and

Yixiong Zheng

3,983 views

11 citations

Original Research

28 July 2022