Interest in research into bioactive peptides from various foods is growing because of their health-promoting ability. Several bioactivities have been ascribed to peptides, including antioxidant, antihypertensive and antimicrobial properties. Implementation of a peptide’s potential biological effect depends largely on its ability to remain intact until reaching the target organ. Research has shown that peptides of different sizes can transport through the gastrointestinal epithelium. The plasma membrane of epithelial cells acts as a major barrier between the inside and the outside of the body, and the free movement of peptides from the lumen to the bloodstream is restricted by the epithelial cell sheets. The epithelial cells create this selective permeability by two pathways: the transcellular and the paracellular pathway. In recent years, research on the permeability of peptides has undergone a sudden and unexpected upheaval, and it is now apparent that research in this field has entered a new phase.
The selective permeability of bioactive peptides after digestion is not yet fully explored. Moreover, the poor stability and limited permeability through the gastrointestinal (GI) tract and epithelia limit the application of peptides in food products. Thus, scientists still don’t fully know if the active molecules responsible for the corresponding bioactive properties are the parental molecules or their metabolites. A variety of research should focus on developing new technologies and mechanisms to overcome them.
This Research Topic aims to contribute to filling the gap in the knowledge about food protein-derived peptides by exhibiting a variety of activities and novel strategies being used to improve oral absorption.
We welcome manuscripts that deal with the following subtopics:
• Developing new technologies to overcome the gastrointestinal epithelium barrier of peptides
• Effects of bioactive peptides on the mucus and tight junction
• Molecular nutrition studies that may help to elucidate the mechanisms connecting bioactive peptides with different transepithelial pathways
• Peptides derived from protein hydrolysates that are highly relevant to absorption enhancers via transport carrier or tight junction
• Potential mediators between bioactive peptides and tight junction
• The application of proteomics, genomic, transcriptomic, and metabolomic analyses in permeability of foodstuff-derived peptides
• The interactions between mucus and peptide
• Peptide modification by chemical methods or physical methods
• Feasible approach for researching the gastrointestinal epithelium absorption of peptides
• Systematic reviews of the above-described sub-topics.
We would also like to acknowledge that Dr. Zhiyang Du (Jilin University, China) acted as a Topic Coordinator and has contributed to the preparation of the proposal of this Research Topic.
Interest in research into bioactive peptides from various foods is growing because of their health-promoting ability. Several bioactivities have been ascribed to peptides, including antioxidant, antihypertensive and antimicrobial properties. Implementation of a peptide’s potential biological effect depends largely on its ability to remain intact until reaching the target organ. Research has shown that peptides of different sizes can transport through the gastrointestinal epithelium. The plasma membrane of epithelial cells acts as a major barrier between the inside and the outside of the body, and the free movement of peptides from the lumen to the bloodstream is restricted by the epithelial cell sheets. The epithelial cells create this selective permeability by two pathways: the transcellular and the paracellular pathway. In recent years, research on the permeability of peptides has undergone a sudden and unexpected upheaval, and it is now apparent that research in this field has entered a new phase.
The selective permeability of bioactive peptides after digestion is not yet fully explored. Moreover, the poor stability and limited permeability through the gastrointestinal (GI) tract and epithelia limit the application of peptides in food products. Thus, scientists still don’t fully know if the active molecules responsible for the corresponding bioactive properties are the parental molecules or their metabolites. A variety of research should focus on developing new technologies and mechanisms to overcome them.
This Research Topic aims to contribute to filling the gap in the knowledge about food protein-derived peptides by exhibiting a variety of activities and novel strategies being used to improve oral absorption.
We welcome manuscripts that deal with the following subtopics:
• Developing new technologies to overcome the gastrointestinal epithelium barrier of peptides
• Effects of bioactive peptides on the mucus and tight junction
• Molecular nutrition studies that may help to elucidate the mechanisms connecting bioactive peptides with different transepithelial pathways
• Peptides derived from protein hydrolysates that are highly relevant to absorption enhancers via transport carrier or tight junction
• Potential mediators between bioactive peptides and tight junction
• The application of proteomics, genomic, transcriptomic, and metabolomic analyses in permeability of foodstuff-derived peptides
• The interactions between mucus and peptide
• Peptide modification by chemical methods or physical methods
• Feasible approach for researching the gastrointestinal epithelium absorption of peptides
• Systematic reviews of the above-described sub-topics.
We would also like to acknowledge that Dr. Zhiyang Du (Jilin University, China) acted as a Topic Coordinator and has contributed to the preparation of the proposal of this Research Topic.
