Nearly one-fifth of the world's population was infected with Mycobacterium tuberculosis. And it was estimated that about 10% of the infected population will finally progress to TB disease. the risk of progressing to Tuberculosis (TB) disease was high in the first 2 years of infection. However, current diagnostics can’t distinguish the status of latent tuberculosis infection induced by remote or recent transmission. Meanwhile, no diagnostics could identify people progressing from latent tuberculosis to TB disease. Nevertheless, blood-based biomarkers, such as Mycobacterium tuberculosis-specific T cells, cytokines, host transcriptional signatures, etc., were studied to tackle the current dilemma of latent tuberculosis infection, and more studies are warranted to be implemented from different areas and ethnic backgrounds. Meanwhile, host comorbidities such as HIV infection, diabetes, etc., are also important in the development of TB disease for latent tuberculosis and are worthwhile to be discussed.
The Research Topic is focused on risk factors either on Mycobacterium tuberculosis or the host in the progression from latent tuberculosis infection to TB disease. We welcome authors to contribute with Original Research articles, Review articles/Mini-review as well as other article types accepted in the journal that include, but are not limited to the following sub-themes:
• Biomarkers involved in the development of tuberculosis are needed to be studied, especially those biomarkers that would be helpful in the differentiation of recent and remote infections of Mycobacterium tuberculosis.
• Comorbidities such as HIV infection, diabetes, etc., among latent tuberculosis infection people that would be associated with increased risk of tuberculosis are needed to be studied.
• The phylogenic of Mycobacterium tuberculosis involved in the recent transmission of tuberculosis needs to be clarified.
• Models in the prediction of the risk of developing tuberculosis disease for latent tuberculosis people based on the current knowledge of host factors including biomarkers, comorbidities, etc., are warranted to be explored.
• Epidemiology studies that could identify risk groups of latent tuberculosis infection in developing tuberculosis are needed.
Nearly one-fifth of the world's population was infected with Mycobacterium tuberculosis. And it was estimated that about 10% of the infected population will finally progress to TB disease. the risk of progressing to Tuberculosis (TB) disease was high in the first 2 years of infection. However, current diagnostics can’t distinguish the status of latent tuberculosis infection induced by remote or recent transmission. Meanwhile, no diagnostics could identify people progressing from latent tuberculosis to TB disease. Nevertheless, blood-based biomarkers, such as Mycobacterium tuberculosis-specific T cells, cytokines, host transcriptional signatures, etc., were studied to tackle the current dilemma of latent tuberculosis infection, and more studies are warranted to be implemented from different areas and ethnic backgrounds. Meanwhile, host comorbidities such as HIV infection, diabetes, etc., are also important in the development of TB disease for latent tuberculosis and are worthwhile to be discussed.
The Research Topic is focused on risk factors either on Mycobacterium tuberculosis or the host in the progression from latent tuberculosis infection to TB disease. We welcome authors to contribute with Original Research articles, Review articles/Mini-review as well as other article types accepted in the journal that include, but are not limited to the following sub-themes:
• Biomarkers involved in the development of tuberculosis are needed to be studied, especially those biomarkers that would be helpful in the differentiation of recent and remote infections of Mycobacterium tuberculosis.
• Comorbidities such as HIV infection, diabetes, etc., among latent tuberculosis infection people that would be associated with increased risk of tuberculosis are needed to be studied.
• The phylogenic of Mycobacterium tuberculosis involved in the recent transmission of tuberculosis needs to be clarified.
• Models in the prediction of the risk of developing tuberculosis disease for latent tuberculosis people based on the current knowledge of host factors including biomarkers, comorbidities, etc., are warranted to be explored.
• Epidemiology studies that could identify risk groups of latent tuberculosis infection in developing tuberculosis are needed.