Association between Oral Microbiota Dysbiosis and the Development of Systemic Conditions

Editorial

18 April 2023

Editorial: Association between oral microbiota dysbiosis and the development of systemic conditions

Zheng Zhang

Jian Zhou

Dong Xia

and

Zuomin Wang

1,766 views

2 citations

Editors

Impact

Original Research

07 March 2023

Effects of topical fluoride application on oral microbiota in young children with severe dental caries

Zhengyan Yang

, 4 more and

Zhi Zhou

5,379 views

4 citations

(A) The Shannon index of oral microbiome between patients with nasopharyngeal biopsy and healthy counterparts. (B) The Shannon index of nasal microbiome between patients with nasopharyngeal biopsy and healthy counterparts. (C) The Shannon index of nasopharyngeal microbiome between patients with nasopharyngeal biopsy and healthy counterparts. Oral represents oral microbiome, nasal represents nasal microbiome, naso represents nasopharyngeal microbiome. "*" represented P<0.05, "**" represented P<0.01.

Original Research

30 November 2022

The human oral – nasopharynx microbiome as a risk screening tool for nasopharyngeal carcinoma

Yu Hao

, 10 more and

Lei Cheng

4,545 views

8 citations

(B) The comparison of Chao 1 index in N, P1, P2, and P3. (C) The comparison of Simpson index in N, P1, P2, and P3. (D) The comparison of Shannon index in N, P1, P2, and P3. (E) PCoA analysis revealing the bacterial communities in N, P1, P2, and P3. * P<0.05, ** P<0.01, *** P<0.001.

Original Research

17 November 2022

Characterizing the supragingival microbiome of healthy pregnant women

Yangyang Zhang

, 4 more and

Jin Zhao

3,901 views

4 citations

(A) Heme-bound assay. qRT-PCR of (B) hmuYR and (C) ihtAB and husAB mRNA expression of P. gingivalis WT, ΔtrkA, and ΔtrkA/trkA strains. Data are presented as means ± SD, normalized to 16S rRNA and compared to WT (2−ΔΔCT). N = 3, *p< 0.05, **p< 0.01.

Original Research

02 November 2022

TrkA serves as a virulence modulator in Porphyromonas gingivalis by maintaining heme acquisition and pathogenesis

Renjie Zou

, 2 more and

Yafei Wu

3,082 views

4 citations

gingivalis-administered group and the control group. The relative mRNA expressions of the genes of interest were normalized to the relative quantity of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA. *p < 0.05, **p < 0.01, ***p < 0.001. N = 6. Data are expressed as the mean ± SEM.

Original Research

10 October 2022

Periodontitis induced by Porphyromonas gingivalis drives impaired glucose metabolism in mice

Ni Kang

, 5 more and

Qingxian Luan

4,143 views

9 citations

(A) The interaction of STAT3 and FOXO1 was detected via co-immunoprecipitation in HaCaT cells. Cell lysate was incubated with FOXO1, STAT3 antibodies or control IgG. The corresponding interacting protein was then detected by western blotting using antibody against STAT3, FOXO1, or IgG. Cell lysate (5%) was used as input positive control. (B) Overexpression of FOXO1 inhibited STAT3 activation and ITGB6 expression. HaCaT cells were transfected with pCMV6-Ctrl or pCMV6-FOXO1 plasmids for 24 h before treatment with or without FSL-1 (100 ng/mL) for 2 h. The protein expression of FOXO1, STAT3, p-STAT3, and ITGB6 was analyzed using western blotting. (C) FOXO1 overexpression inhibited phosphorated STAT3 binding to the ITGB6 promoter. HaCaT cells were transfected with pCMV6-Ctrl or pCMV6-FOXO1 plasmids for 24 h. The binding of phosphorated STAT3 to the ITGB6 promoter was detected by ChIP assay. The associated ITGB6 promoter DNA was amplified by qPCR using primers covering the potential STAT3-binding sites from −289/−150 of ITGB6 promoter. The input was 5% of the total cell lysate. Data are shown as mean ± SEM of triplicates and compared, V6-Ctrl group. *P < 0.05, **P < 0.01, ***P < 0.001.

Original Research

10 October 2022

FOXO1 inhibits FSL-1 regulation of integrin β6 by blocking STAT3 binding to the integrin β6 gene promoter

Mingyan Xu

, 4 more and

Xiaoling Deng

2,989 views

3 citations

Review

02 September 2022

The impact of periodontitis on vascular endothelial dysfunction

Qian Li

, 1 more and

Jiang Lin

Periodontitis, an oral inflammatory disease, originates from periodontal microbiota dysbiosis which is associated with the dysregulation of host immunoinflammatory response. This chronic infection is not only harmful to oral health but is also a risk factor for the onset and progress of various vascular diseases, such as hypertension, atherosclerosis, and coronary arterial disease. Vascular endothelial dysfunction is the initial key pathological feature of vascular diseases. Clarifying the association between periodontitis and vascular endothelial dysfunction is undoubtedly a key breakthrough for understanding the potential relationship between periodontitis and vascular diseases. However, there is currently a lack of an updated review of their relationship. Therefore, we aim to focus on the implications of periodontitis in vascular endothelial dysfunction in this review.

5,099 views

26 citations

Significant differences between the relative frequencies of the complexes in each group were evaluated using the Kruskal-Wallis chi-square method; *p-value < 0.05, **p-value < 0.01.

Original Research

15 September 2022

Patients with obstructive sleep apnea can favor the predisposing factors of periodontitis by the presence of P. melaninogenica and C. albicans, increasing the severity of the periodontal disease

Mayra A. Téllez-Corral

, 11 more and

Claudia M. Parra-Giraldo

4,618 views

16 citations

Review

16 August 2022

Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects

Xiaohui Xu

, 7 more and

Jinlin Song

Periodontitis is highly prevalent worldwide. It is characterized by periodontal attachment and alveolar bone destruction, which not only leads to tooth loss but also results in the exacerbation of systematic diseases. As such, periodontitis has a significant negative impact on the daily lives of patients. Detailed exploration of the molecular mechanisms underlying the physiopathology of periodontitis may contribute to the development of new therapeutic strategies for periodontitis and the associated systematic diseases. Pyroptosis, as one of the inflammatory programmed cell death pathways, is implicated in the pathogenesis of periodontitis. Progress in the field of pyroptosis has greatly enhanced our understanding of its role in inflammatory diseases. This review first summarizes the mechanisms underlying the activation of pyroptosis in periodontitis and the pathological role of pyroptosis in the progression of periodontitis. Then, the crosstalk between pyroptosis with apoptosis, necroptosis, and NETosis in periodontitis is discussed. Moreover, pyroptosis, as a novel link that connects periodontitis with systemic disease, is also reviewed. Finally, the current challenges associated with pyroptosis as a potential therapeutic target for periodontitis are highlighted.

10,055 views

21 citations