The onset of type 2 diabetes (T2D) is often preceded by an asymptomatic condition known as prediabetes where glucose levels are above the normal range but below the threshold for the diagnosis of T2D.
Recent studies have shown that a number of complications associated with T2D begin and progress during prediabetes. Additionally, more studies have shown that the intermediate hyperglycemia associated with prediabetes may result in chronic sub-clinical inflammation and increased generation of reactive oxygen species (ROS). This may have consequences on thyroid, renal, hepatic, and immune function, to name a few.
The effects of hyperglycemia, inflammation, and ROS generation in relation to endocrine function are well-documented in T2D, however, these effects are not yet fully understood in the prediabetic state. In this Research Topic, we welcome papers looking at the effects of prediabetes on endocrine function and how this could affect homeostasis as well as the body’s response to disease. This Topic aims to increase the understanding of fundamental aspects of prediabetes as it is a condition that can be targeted to prevent T2D and the associated complications.
The onset of type 2 diabetes (T2D) is often preceded by an asymptomatic condition known as prediabetes where glucose levels are above the normal range but below the threshold for the diagnosis of T2D.
Recent studies have shown that a number of complications associated with T2D begin and progress during prediabetes. Additionally, more studies have shown that the intermediate hyperglycemia associated with prediabetes may result in chronic sub-clinical inflammation and increased generation of reactive oxygen species (ROS). This may have consequences on thyroid, renal, hepatic, and immune function, to name a few.
The effects of hyperglycemia, inflammation, and ROS generation in relation to endocrine function are well-documented in T2D, however, these effects are not yet fully understood in the prediabetic state. In this Research Topic, we welcome papers looking at the effects of prediabetes on endocrine function and how this could affect homeostasis as well as the body’s response to disease. This Topic aims to increase the understanding of fundamental aspects of prediabetes as it is a condition that can be targeted to prevent T2D and the associated complications.