Hemodynamics studies the behaviour of blood flow in the circulatory system. Abnormal blood flow has been found to be closely related to the onset and development of a wide range of cardiovascular diseases such as hypertension, atherosclerosis, valvular heart disease, and heart failure. The hemodynamic mechanism underlying the pathogenesis of cardiovascular diseases can be complex, multiscale, and multifactorial. At the macroscale, the change in blood flow often leads to a reduced flow pumping of the heart, which required the myocardium to work harder to compensate. Such increased workload is often spatially uneven and temporally dyssynchronous, which leads to a progressive process of ventricular remodelling and functional deterioration.
Recent developments in flow imaging and computational fluid dynamics have equipped physicians and researchers with better tools to investigate blood flow in patients and delivered novel insights into the pathophysiology of cardiovascular disease. This Research Topic will provide a contemporary update of the advances of hemodynamic analysis in cardiovascular diseases, including the state-of-the-art flow imaging tools and computational fluid dynamics technologies. Along with this, novel applications, such as new hemodynamic biomarkers and algorithms to elucidate the pathophysiology and improve the prevention and treatment of cardiovascular diseases are encouraged. This Research Topic is open to all article types accepted by Frontiers including original research and review articles, with a particular focus on further insights into this exciting research area.
Current research of hemodynamic and hemorheology focuses on the role of intrinsic characteristics of blood in the development of atherosclerosis. Atherosclerosis is a very complex disease involving different pathways, and its clinical complications are among the major causes of death in the general population. Research has provided evidence that blood flow characteristics such as shear stress, tensile stress, oscillatory stress, and blood properties such as hematocrit, blood viscosity, red cell aggregation and deformability, platelet aggregation, white blood cells activation are associated with plaque development or endothelial dysfunction. Abnormalities in hemorheology and hemodynamics are associated with major cardiovascular risk factors and might be responsible for the residual cardiovascular risk even when appropriate pharmacological therapy is provided.
Hemodynamics studies the behaviour of blood flow in the circulatory system. Abnormal blood flow has been found to be closely related to the onset and development of a wide range of cardiovascular diseases such as hypertension, atherosclerosis, valvular heart disease, and heart failure. The hemodynamic mechanism underlying the pathogenesis of cardiovascular diseases can be complex, multiscale, and multifactorial. At the macroscale, the change in blood flow often leads to a reduced flow pumping of the heart, which required the myocardium to work harder to compensate. Such increased workload is often spatially uneven and temporally dyssynchronous, which leads to a progressive process of ventricular remodelling and functional deterioration.
Recent developments in flow imaging and computational fluid dynamics have equipped physicians and researchers with better tools to investigate blood flow in patients and delivered novel insights into the pathophysiology of cardiovascular disease. This Research Topic will provide a contemporary update of the advances of hemodynamic analysis in cardiovascular diseases, including the state-of-the-art flow imaging tools and computational fluid dynamics technologies. Along with this, novel applications, such as new hemodynamic biomarkers and algorithms to elucidate the pathophysiology and improve the prevention and treatment of cardiovascular diseases are encouraged. This Research Topic is open to all article types accepted by Frontiers including original research and review articles, with a particular focus on further insights into this exciting research area.
Current research of hemodynamic and hemorheology focuses on the role of intrinsic characteristics of blood in the development of atherosclerosis. Atherosclerosis is a very complex disease involving different pathways, and its clinical complications are among the major causes of death in the general population. Research has provided evidence that blood flow characteristics such as shear stress, tensile stress, oscillatory stress, and blood properties such as hematocrit, blood viscosity, red cell aggregation and deformability, platelet aggregation, white blood cells activation are associated with plaque development or endothelial dysfunction. Abnormalities in hemorheology and hemodynamics are associated with major cardiovascular risk factors and might be responsible for the residual cardiovascular risk even when appropriate pharmacological therapy is provided.