Genetic variation is one of the most important risk factors in various human disease such as cancer, metabolic syndrome, and diabetes etc. Genome-wide association studies (GWASs) have quantified and statistically describes associations between genetic variants and diseases. Advanced cellular and animal disease models have promoted the research of human disease from simple phenomenological observation to sophisticated biochemistry and molecular mechanism study in the post-GWAS era. Scientists are focusing on molecular mechanisms of human diseases for early disease diagnosis and new drug target discovery by using human disease models. Human disease model studies based on human cancer cell lines and mouse have been successfully translated into clinical application. The heterogeneity and complexity of human disease require the cutting-age technology such as CRISPR-cas9 and Prime editing to better explore the potential mechanisms of human diseases models.
This Research Topic aims to gather recent research in human disease models of functional genetic studies. This topic illustrates cutting-age technologies to explore the association between causal genetic variants and biological mechanisms from human disease models in the post-GWAS era. Primary cell disease models that originate from cells or tissues of patients can more realistically mimic in vivo cell culture systems and sustain fully functional disease cells. Organoids derived from patients morphologically and functionally mimic important aspects of human disease. Moreover, genetically engineered animal models from mice, monkey and minipig have greatly enhanced the understanding of functional genetics. This collection of cellular and animal disease models of functional genetics would further provide cutting age methodology and greatly contribute for further biochemistry and molecular mechanism research.
The Research Topic aims to gather recent research in the human disease models for functional genetics studies.
This Research Topic welcomes Original Research, and Review articles covering subjects related, but not limited, to:
-The methodology of functional genetics in human disease models
-Genetically engineered human disease animal models such as mice, monkey, minipig etc.
-Patient-derived xenograft genetic models
-Human disease animal models induced by chemical or diet etc.
-Technologies used for the disease model as CRISP-Cas9, prim editing etc.
Genetic variation is one of the most important risk factors in various human disease such as cancer, metabolic syndrome, and diabetes etc. Genome-wide association studies (GWASs) have quantified and statistically describes associations between genetic variants and diseases. Advanced cellular and animal disease models have promoted the research of human disease from simple phenomenological observation to sophisticated biochemistry and molecular mechanism study in the post-GWAS era. Scientists are focusing on molecular mechanisms of human diseases for early disease diagnosis and new drug target discovery by using human disease models. Human disease model studies based on human cancer cell lines and mouse have been successfully translated into clinical application. The heterogeneity and complexity of human disease require the cutting-age technology such as CRISPR-cas9 and Prime editing to better explore the potential mechanisms of human diseases models.
This Research Topic aims to gather recent research in human disease models of functional genetic studies. This topic illustrates cutting-age technologies to explore the association between causal genetic variants and biological mechanisms from human disease models in the post-GWAS era. Primary cell disease models that originate from cells or tissues of patients can more realistically mimic in vivo cell culture systems and sustain fully functional disease cells. Organoids derived from patients morphologically and functionally mimic important aspects of human disease. Moreover, genetically engineered animal models from mice, monkey and minipig have greatly enhanced the understanding of functional genetics. This collection of cellular and animal disease models of functional genetics would further provide cutting age methodology and greatly contribute for further biochemistry and molecular mechanism research.
The Research Topic aims to gather recent research in the human disease models for functional genetics studies.
This Research Topic welcomes Original Research, and Review articles covering subjects related, but not limited, to:
-The methodology of functional genetics in human disease models
-Genetically engineered human disease animal models such as mice, monkey, minipig etc.
-Patient-derived xenograft genetic models
-Human disease animal models induced by chemical or diet etc.
-Technologies used for the disease model as CRISP-Cas9, prim editing etc.
