Recently, much attention has been paid to the study of bioactive peptides from various marine organisms, including algae, fish, mollusks, and crustaceans. Marine-derived peptides have been reported to exhibit broad-spectrum biological activities and therapeutic potential, such as anti-cancer, antimicrobial, antiviral, antioxidative, cardioprotective, immunomodulatory, analgesic, anxiolytic anti-diabetic, appetite suppressing and neuroprotective activities.
Due to their unique advantages such as smaller size, simpler manufacturing, being readily modified, low drug-drug interaction, fewer adverse side effects compared to proteins and antibodies, marine-derived peptides have become a significant source of anti-cancer drugs. Indeed, anti-cancer peptides have been isolated from cyanobacteria, fungi, sponges, tunicates, ascidians, mollusks, and fish. In addition, marine animal venoms provide a rich source of bioactive neuroactive peptides, targeting the central nervous system through affinity with ion channels/receptors, which could shed light for drug discovery to treat a variety of diseases, from pain to autoimmune and neurological diseases. Marine organisms also use neuropeptides, the most diverse class of neurotransmitters/neuromodulators, to regulate various physiological functions crucial to their survival and adaptiveness.
This Research Topic aims to explore the potential of bioactive peptides from marine sources, highlighting their potential for drug discovery and development. The Research Topic will focus on the identification, structural elucidation, functional characterization, and pharmacological mechanisms of marine-derived peptides.
Subtopics will include, but are not limited to:
• Discovery, identification and biological evaluation of marine-derived peptides
• Structure-activity relationships
• Novel methods or platforms to improve the drug discovery process of peptides
• The regulatory role of marine peptides on sleep, feeding, social behaviors and other motivated behaviors, and the mechanism of action
• Marine peptides as drug leads for anti-cancer, ant-inflammatory and pain management agents
• The pharmacology, pharmacokinetics and pharmacodynamics of marine-derived peptides as drug leads
Submissions containing data with crude extracts or mixtures, and submissions containing in silico only data will not be considered.
Recently, much attention has been paid to the study of bioactive peptides from various marine organisms, including algae, fish, mollusks, and crustaceans. Marine-derived peptides have been reported to exhibit broad-spectrum biological activities and therapeutic potential, such as anti-cancer, antimicrobial, antiviral, antioxidative, cardioprotective, immunomodulatory, analgesic, anxiolytic anti-diabetic, appetite suppressing and neuroprotective activities.
Due to their unique advantages such as smaller size, simpler manufacturing, being readily modified, low drug-drug interaction, fewer adverse side effects compared to proteins and antibodies, marine-derived peptides have become a significant source of anti-cancer drugs. Indeed, anti-cancer peptides have been isolated from cyanobacteria, fungi, sponges, tunicates, ascidians, mollusks, and fish. In addition, marine animal venoms provide a rich source of bioactive neuroactive peptides, targeting the central nervous system through affinity with ion channels/receptors, which could shed light for drug discovery to treat a variety of diseases, from pain to autoimmune and neurological diseases. Marine organisms also use neuropeptides, the most diverse class of neurotransmitters/neuromodulators, to regulate various physiological functions crucial to their survival and adaptiveness.
This Research Topic aims to explore the potential of bioactive peptides from marine sources, highlighting their potential for drug discovery and development. The Research Topic will focus on the identification, structural elucidation, functional characterization, and pharmacological mechanisms of marine-derived peptides.
Subtopics will include, but are not limited to:
• Discovery, identification and biological evaluation of marine-derived peptides
• Structure-activity relationships
• Novel methods or platforms to improve the drug discovery process of peptides
• The regulatory role of marine peptides on sleep, feeding, social behaviors and other motivated behaviors, and the mechanism of action
• Marine peptides as drug leads for anti-cancer, ant-inflammatory and pain management agents
• The pharmacology, pharmacokinetics and pharmacodynamics of marine-derived peptides as drug leads
Submissions containing data with crude extracts or mixtures, and submissions containing in silico only data will not be considered.