Cancer progression results from the deregulation of signaling pathways that contribute to epigenetic or genetic modifications or derangements. This can cause a huge shift in the cellular environment and has been considered to contribute to chemotherapeutic drug resistance. Most chemotherapeutic drugs target a signaling pathway that controls cell proliferation, invasion or cell migration, and that is mediated by extracellular stimuli travelling from the plasma membrane to the nucleus. Despite the development of specific small molecules that show significant efficacy towards protein kinases or other proteins orchestrating the signaling cascades that propel cancer metastasis, challenges such as the development of resistance impair the use of individual inhibitors and continue to be the principal limiting factor to achieving cures. As a result, combinational treatments might offer a valid alternative to overcome drug resistance in cancer and further study on drug repurposing and combined treatment should be undertaken
This Research Topic will provide a platform to publish research exploring the molecular mechanisms, effects and efficiency of combinatorial treatments in cancer. The collection will also highlight studies that address drug repurposing (also known as drug repositioning) and solicit discussion about the challenges faced by the repurposing research community, and recommendations for innovative ways to address drug resistance in cancer.
This research topic welcomes original research articles and review articles focusing on, but not limited to:
-Molecular mechanisms of combination treatments and therapies in cancer
-Treatment approaches that specifically target or reduce drug resistance
-Computational approaches such as signature matching, molecular docking, pathways, and network
-Recent advances in single cell analysis and 3D bioprinting within the field of drug re-purposing.
Cancer progression results from the deregulation of signaling pathways that contribute to epigenetic or genetic modifications or derangements. This can cause a huge shift in the cellular environment and has been considered to contribute to chemotherapeutic drug resistance. Most chemotherapeutic drugs target a signaling pathway that controls cell proliferation, invasion or cell migration, and that is mediated by extracellular stimuli travelling from the plasma membrane to the nucleus. Despite the development of specific small molecules that show significant efficacy towards protein kinases or other proteins orchestrating the signaling cascades that propel cancer metastasis, challenges such as the development of resistance impair the use of individual inhibitors and continue to be the principal limiting factor to achieving cures. As a result, combinational treatments might offer a valid alternative to overcome drug resistance in cancer and further study on drug repurposing and combined treatment should be undertaken
This Research Topic will provide a platform to publish research exploring the molecular mechanisms, effects and efficiency of combinatorial treatments in cancer. The collection will also highlight studies that address drug repurposing (also known as drug repositioning) and solicit discussion about the challenges faced by the repurposing research community, and recommendations for innovative ways to address drug resistance in cancer.
This research topic welcomes original research articles and review articles focusing on, but not limited to:
-Molecular mechanisms of combination treatments and therapies in cancer
-Treatment approaches that specifically target or reduce drug resistance
-Computational approaches such as signature matching, molecular docking, pathways, and network
-Recent advances in single cell analysis and 3D bioprinting within the field of drug re-purposing.