In the past years, it has become evident that long non-coding RNAs (lncRNAs) play an important role in the regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. lncRNAs can regulate gene expression through the interaction with RNA binding proteins (RBPs) and with other lncRNAs, and through the lncRNA-encoded micropeptides.
Given their prominent role in gene regulation, lncRNA biology is strictly regulated by post-transcriptional modifications that affect their stability and nuclear trafficking.
Since the lncRNA research develops at a rapid pace, it is imperative to provide updates on this front. In this Research Topic, we will cover various aspects of lncRNA-mediated gene expression, and their role in promoting cancer progression and metastasis. We also aim to address the interplay between lncRNAs and RNA binding proteins, and how lncRNAs are regulated in cancer.
We welcome Original Research, Reviews, and Mini-Review articles focusing on but not limited to the following topics and their role in cancerogenesis and cancer progression:
- Epigenetic regulation of lncRNAs
- RNA-binding proteins
- lncRNA splicing
- lncRNA stability
- Nuclear trafficking
- lncRNA-encoded micropeptides
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
In the past years, it has become evident that long non-coding RNAs (lncRNAs) play an important role in the regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. lncRNAs can regulate gene expression through the interaction with RNA binding proteins (RBPs) and with other lncRNAs, and through the lncRNA-encoded micropeptides.
Given their prominent role in gene regulation, lncRNA biology is strictly regulated by post-transcriptional modifications that affect their stability and nuclear trafficking.
Since the lncRNA research develops at a rapid pace, it is imperative to provide updates on this front. In this Research Topic, we will cover various aspects of lncRNA-mediated gene expression, and their role in promoting cancer progression and metastasis. We also aim to address the interplay between lncRNAs and RNA binding proteins, and how lncRNAs are regulated in cancer.
We welcome Original Research, Reviews, and Mini-Review articles focusing on but not limited to the following topics and their role in cancerogenesis and cancer progression:
- Epigenetic regulation of lncRNAs
- RNA-binding proteins
- lncRNA splicing
- lncRNA stability
- Nuclear trafficking
- lncRNA-encoded micropeptides
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
