Psychotic disorders are a form of severe mental disorder that have a devastating impact on the socio-occupational functioning of the sufferer. Schizophrenia, delusional disorder, bipolar disorder, psychosis in the context of severe depressive disorder, substance use disorders, and others fall into the broad category of psychotic disorders. Managing psychosis always poses a challenge to mental health professionals, and more so when treatment resistance is
encountered. This requires revising the primary diagnosis and gearing up the existing treatment armamentarium so as to treat and rehabilitate the sufferer. No matter whatever newer or novel treatment options are employed to tackle treatment resistance, there always remains a need for further research in this domain.
Treatment resistance in psychotic disorders poses significant challenges both to sufferers and to mental health professionals. Since the gamut of psychotic disorders is large as far as individual diagnostic groups in nosologies are concerned, no particular management plan for one group of psychosis is a good fit for others. Researchers are invited to put forward their papers and ideas on how to manage treatment resistance or refractoriness across the entire range of psychotic disorders, including but not limited to, papers on pharmacological as well as non-pharmacological approaches to the problem. These can also include discussion or comments on various treatment guidelines, neuroimaging, psycho-neuro-immunological perspectives to treatment resistance, and molecular and genetic pathways involved. Papers discussing novel diagnostic and technological aspects of treatment resistance in psychosis are also welcome. Overall, the goal for this Research Topic is to understand, diagnose, and tackle treatment resistance in psychosis from a holistic perspective that can be translated from bench to bedside.
We invite articles (meta-analyses and systematic reviews, clinical trials, cohort and case-control studies) on:
• The critical evaluation of various diagnostic algorithms for treatment resistance in psychotic disorders.
• The neurobiology (including but not restricted to genetics, epigenetics, endophenotypes etc.) of treatment resistance in psychosis.
• The cellular or molecular mechanisms to treatment resistance in psychosis.
• Critical evaluation of various guidelines to manage treatment resistance in psychosis.
• Various pharmacological and non-pharmacological approaches to the problem, including clinical trials, meta-analyses and systematic reviews.
• The interface between treatment resistance in psychosis and other fields of medicine.
• Novel techniques in diagnostics and therapeutics for treatment resistance in psychosis.
• Rehabilitation in Psychotic disorders when treatment resistance is encountered.
Psychotic disorders are a form of severe mental disorder that have a devastating impact on the socio-occupational functioning of the sufferer. Schizophrenia, delusional disorder, bipolar disorder, psychosis in the context of severe depressive disorder, substance use disorders, and others fall into the broad category of psychotic disorders. Managing psychosis always poses a challenge to mental health professionals, and more so when treatment resistance is
encountered. This requires revising the primary diagnosis and gearing up the existing treatment armamentarium so as to treat and rehabilitate the sufferer. No matter whatever newer or novel treatment options are employed to tackle treatment resistance, there always remains a need for further research in this domain.
Treatment resistance in psychotic disorders poses significant challenges both to sufferers and to mental health professionals. Since the gamut of psychotic disorders is large as far as individual diagnostic groups in nosologies are concerned, no particular management plan for one group of psychosis is a good fit for others. Researchers are invited to put forward their papers and ideas on how to manage treatment resistance or refractoriness across the entire range of psychotic disorders, including but not limited to, papers on pharmacological as well as non-pharmacological approaches to the problem. These can also include discussion or comments on various treatment guidelines, neuroimaging, psycho-neuro-immunological perspectives to treatment resistance, and molecular and genetic pathways involved. Papers discussing novel diagnostic and technological aspects of treatment resistance in psychosis are also welcome. Overall, the goal for this Research Topic is to understand, diagnose, and tackle treatment resistance in psychosis from a holistic perspective that can be translated from bench to bedside.
We invite articles (meta-analyses and systematic reviews, clinical trials, cohort and case-control studies) on:
• The critical evaluation of various diagnostic algorithms for treatment resistance in psychotic disorders.
• The neurobiology (including but not restricted to genetics, epigenetics, endophenotypes etc.) of treatment resistance in psychosis.
• The cellular or molecular mechanisms to treatment resistance in psychosis.
• Critical evaluation of various guidelines to manage treatment resistance in psychosis.
• Various pharmacological and non-pharmacological approaches to the problem, including clinical trials, meta-analyses and systematic reviews.
• The interface between treatment resistance in psychosis and other fields of medicine.
• Novel techniques in diagnostics and therapeutics for treatment resistance in psychosis.
• Rehabilitation in Psychotic disorders when treatment resistance is encountered.
