Cardiovascular diseases (CVDs) are currently the leading cause of death across the globe. Genetic mutations are a major underlying factor in CVD for a substantial proportion of both familial and sporadic cases. Despite the increasing number of genes and loci identified, genetic studies of many patients (~ 50%) reveal the absence of a reported pathogenic gene mutation. In addition, the precise mechanisms by which many of these genes influence CVDs are often unknown.
Recent advances in developing and optimizing high-throughput technologies involving the generation of "omics data" and stem cell models have provided opportunities for in-depth study of the genetic basis of CVDs and related tailor-made therapies.
In this Research Topic, we aim to promote scientific and clinical research focusing on understanding the molecular framework and intricacies of CVDs through the use of omics data, stem cells, and animal models, towards a precision medicine approach. We hope to address the current gaps in CVD genomics, stem cells, precision evidence approaches, and potential limitations and future directions of this emerging field.
Potential sub-topics include:
1) Novel genetic and epigenetic association and its related mechanisms causing CVDs.
2) Known genes with new mechanistic biology that enhance the precision medicine approach.
3) Novel molecular signaling pathways in the pathogenesis of the CVDs.
4) Stem models for understanding cardiac disease and related therapeutic avenues.
5) Technologies enabling cardiac stem-cell-based precision medicine.
6) Future research perspective to enhance our knowledge in the genomics-based therapies.
We welcome Original Articles, Review, Case Reports, and Clinical Studies.
Cardiovascular diseases (CVDs) are currently the leading cause of death across the globe. Genetic mutations are a major underlying factor in CVD for a substantial proportion of both familial and sporadic cases. Despite the increasing number of genes and loci identified, genetic studies of many patients (~ 50%) reveal the absence of a reported pathogenic gene mutation. In addition, the precise mechanisms by which many of these genes influence CVDs are often unknown.
Recent advances in developing and optimizing high-throughput technologies involving the generation of "omics data" and stem cell models have provided opportunities for in-depth study of the genetic basis of CVDs and related tailor-made therapies.
In this Research Topic, we aim to promote scientific and clinical research focusing on understanding the molecular framework and intricacies of CVDs through the use of omics data, stem cells, and animal models, towards a precision medicine approach. We hope to address the current gaps in CVD genomics, stem cells, precision evidence approaches, and potential limitations and future directions of this emerging field.
Potential sub-topics include:
1) Novel genetic and epigenetic association and its related mechanisms causing CVDs.
2) Known genes with new mechanistic biology that enhance the precision medicine approach.
3) Novel molecular signaling pathways in the pathogenesis of the CVDs.
4) Stem models for understanding cardiac disease and related therapeutic avenues.
5) Technologies enabling cardiac stem-cell-based precision medicine.
6) Future research perspective to enhance our knowledge in the genomics-based therapies.
We welcome Original Articles, Review, Case Reports, and Clinical Studies.