Mitogen-activated protein kinases (MAPKS) are protein kinases that phosphorylate their own dual serine and threonine residues, or those found on their substrates, to activate or inhibit their targets. MAPKS have a major role in cellular proliferation and survival and their deregulation can be involved in uncontrolled cell growth.
Mitogen-activated protein 4 kinase 4 (MAP4K4) plays a critical role in MLK3-mediated MAP Kinase signaling and it has been found correlated with KRAS oncoprotein in cancer.
Information regarding MAP4K4 in cancers is limited, but increasing evidence suggests that MAP4K4 plays an important role in cancer. Further investigations on MAP4K4 might lead to identification of novel cancer prognostic biomarkers but also of valid targets for anticancer therapy. Exhaustive molecular understanding of how MAP4K4 is involved in cancer biology is essential to firmly establish MAP4K4 as a cancer drug target.
This special issue is aimed to improve the understanding of the relationship between the components of MAPKs pathway, in particular MAP4K4, and carcinogenesis and cancer progression. We also welcome novel discoveries regarding the possibility to therapeutically target the MP4K4 signaling pathway.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Mitogen-activated protein kinases (MAPKS) are protein kinases that phosphorylate their own dual serine and threonine residues, or those found on their substrates, to activate or inhibit their targets. MAPKS have a major role in cellular proliferation and survival and their deregulation can be involved in uncontrolled cell growth.
Mitogen-activated protein 4 kinase 4 (MAP4K4) plays a critical role in MLK3-mediated MAP Kinase signaling and it has been found correlated with KRAS oncoprotein in cancer.
Information regarding MAP4K4 in cancers is limited, but increasing evidence suggests that MAP4K4 plays an important role in cancer. Further investigations on MAP4K4 might lead to identification of novel cancer prognostic biomarkers but also of valid targets for anticancer therapy. Exhaustive molecular understanding of how MAP4K4 is involved in cancer biology is essential to firmly establish MAP4K4 as a cancer drug target.
This special issue is aimed to improve the understanding of the relationship between the components of MAPKs pathway, in particular MAP4K4, and carcinogenesis and cancer progression. We also welcome novel discoveries regarding the possibility to therapeutically target the MP4K4 signaling pathway.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.