From atherosclerotic plaque to oesophagal cancer and inflammatory bowel disease, clinicians rely on direct visualization of and detection of properties from the surface of hollow organs to diagnose, treat, and monitor diseases. Minimally-invasive intraluminal imaging systems and optical sensing devices go beyond white light imaging to provide macroscopic and microscopic biochemical, functional, and structural/morphological information with clinical value. Technical improvements in miniaturization and high precision optoelectronics and optomechanics translate into sophisticated intraluminal imaging and sensing devices capable of seeing previously inaccessible areas in the human body. In parallel, advanced image and signal analysis methods and validation strategies are in continuous development to understand the biomedical and clinical meaning of these often multidimensional datasets.
The objective of this Research Topic is to provide a status report on the state-of-the-art in intraluminal imaging and optical sensing technologies at the stage of clinical translation. We aim to compile a collection of articles that cover the multidisciplinary activities involved in clinical intraluminal imaging and optical sensing. We welcome original research in instrument design and manufacturing, results from experimentation in clinical settings, and image analysis methods and validation approaches. Also of interest to the community are review articles that provide context to the field of intraluminal imaging and optical sensings such as the history of hollow organ imaging, current clinical needs, and prospects for the future of the field.
The scope of this Research Topic is focused on the development and clinical use of intraluminal imaging and sensing biophotonic technologies. Themes under consideration include:
1. Original research on instrument design and development for clinical use.
2. Tutorials on instrument considerations for clinical devices for intraluminal imaging and sensing (from design parameters to characterization and calibration, and safety and regulatory aspects).
3. Clinical and preclinical trials demonstrating the performance of intraluminal imaging and sensing devices.
4. Essays on validation strategies (from validation phantoms to coregistration with histopathology and clinical imaging).
5. Review articles on historical milestones, innovative perspectives, and clinical needs for intraluminal imaging and sensing.
The biophotonic imaging modalities under consideration include, but are not limited to, reflectance spectroscopy, diffuse optical imaging, fluorescence spectroscopy, hyperspectral imaging, Raman spectroscopy, optical coherence tomography, photoacoustics, polarization-based imaging, nonlinear optical imaging. Examples of clinical applications for intraluminal imaging and sensing range from cancer detection to monitoring inflammatory and infectious diseases in the gastrointestinal tract, the respiratory system, the reproductive tract, and the cardiovascular system.
From atherosclerotic plaque to oesophagal cancer and inflammatory bowel disease, clinicians rely on direct visualization of and detection of properties from the surface of hollow organs to diagnose, treat, and monitor diseases. Minimally-invasive intraluminal imaging systems and optical sensing devices go beyond white light imaging to provide macroscopic and microscopic biochemical, functional, and structural/morphological information with clinical value. Technical improvements in miniaturization and high precision optoelectronics and optomechanics translate into sophisticated intraluminal imaging and sensing devices capable of seeing previously inaccessible areas in the human body. In parallel, advanced image and signal analysis methods and validation strategies are in continuous development to understand the biomedical and clinical meaning of these often multidimensional datasets.
The objective of this Research Topic is to provide a status report on the state-of-the-art in intraluminal imaging and optical sensing technologies at the stage of clinical translation. We aim to compile a collection of articles that cover the multidisciplinary activities involved in clinical intraluminal imaging and optical sensing. We welcome original research in instrument design and manufacturing, results from experimentation in clinical settings, and image analysis methods and validation approaches. Also of interest to the community are review articles that provide context to the field of intraluminal imaging and optical sensings such as the history of hollow organ imaging, current clinical needs, and prospects for the future of the field.
The scope of this Research Topic is focused on the development and clinical use of intraluminal imaging and sensing biophotonic technologies. Themes under consideration include:
1. Original research on instrument design and development for clinical use.
2. Tutorials on instrument considerations for clinical devices for intraluminal imaging and sensing (from design parameters to characterization and calibration, and safety and regulatory aspects).
3. Clinical and preclinical trials demonstrating the performance of intraluminal imaging and sensing devices.
4. Essays on validation strategies (from validation phantoms to coregistration with histopathology and clinical imaging).
5. Review articles on historical milestones, innovative perspectives, and clinical needs for intraluminal imaging and sensing.
The biophotonic imaging modalities under consideration include, but are not limited to, reflectance spectroscopy, diffuse optical imaging, fluorescence spectroscopy, hyperspectral imaging, Raman spectroscopy, optical coherence tomography, photoacoustics, polarization-based imaging, nonlinear optical imaging. Examples of clinical applications for intraluminal imaging and sensing range from cancer detection to monitoring inflammatory and infectious diseases in the gastrointestinal tract, the respiratory system, the reproductive tract, and the cardiovascular system.