Cardiovascular Diseases (CVDs) are the leading cause of death worldwide. A growing body of evidence have linked the (patho)physiology of CVDs (endothelial damage, vascular inflammation and atherosclerotic plaque formation etc.) to various types of receptors including transmembrane and intracellular receptors. These receptors can also be categorized as channel-linked receptors, enzyme-linked receptors, G-protein-coupled receptors and nuclear receptors, depending on their structures and functions.
Despite the sheer volume of research and discussion on the correlation between receptor and CVDs, additional questions still remain to be addressed:
1) What are the commonality and uniqueness of different types of cellular receptors in mediating the development of CVDs such as hypertension, myocardial infarction, atherosclerosis and heart failure?
2) What are the underlying interactions of the signaling pathways mediated by cellular receptors between the heart and other organs (liver, kidney, lung, brain, etc.) and the role in disease progression?
3) What the is the importance of receptors-targeting strategy in the future research area of CVD diagnosis and treatment?
4) Drugs targeting the glucagon-like peptide-1 receptor and sodium-glucose cotransporter-2 have been have been recently recommended in patients with CVDs. However, is the clinical application of these drugs in the real world associated with any heath risks, considering the critical physiological function a receptor?
In this Research Topic, we hope to promote scientific and clinical research focusing on the unique role of receptors in CVDs and provide insights into the discovery of novel strategies targeting receptors in the diagnosis, prevention and treatment of CVDs.
Topics of interest include:
1) Novel mechanisms underlying the involvement of cell receptors in CVDs.
2) Interactions between cell receptors and their signaling pathways in the cardiovascular system and other organs.
3) Update on the use of drugs targeting receptors in the prevention and treatment of CVDs.
4) Studies that provide future research to promote our knowledge in the research area of CVDs and receptors.
Cardiovascular Diseases (CVDs) are the leading cause of death worldwide. A growing body of evidence have linked the (patho)physiology of CVDs (endothelial damage, vascular inflammation and atherosclerotic plaque formation etc.) to various types of receptors including transmembrane and intracellular receptors. These receptors can also be categorized as channel-linked receptors, enzyme-linked receptors, G-protein-coupled receptors and nuclear receptors, depending on their structures and functions.
Despite the sheer volume of research and discussion on the correlation between receptor and CVDs, additional questions still remain to be addressed:
1) What are the commonality and uniqueness of different types of cellular receptors in mediating the development of CVDs such as hypertension, myocardial infarction, atherosclerosis and heart failure?
2) What are the underlying interactions of the signaling pathways mediated by cellular receptors between the heart and other organs (liver, kidney, lung, brain, etc.) and the role in disease progression?
3) What the is the importance of receptors-targeting strategy in the future research area of CVD diagnosis and treatment?
4) Drugs targeting the glucagon-like peptide-1 receptor and sodium-glucose cotransporter-2 have been have been recently recommended in patients with CVDs. However, is the clinical application of these drugs in the real world associated with any heath risks, considering the critical physiological function a receptor?
In this Research Topic, we hope to promote scientific and clinical research focusing on the unique role of receptors in CVDs and provide insights into the discovery of novel strategies targeting receptors in the diagnosis, prevention and treatment of CVDs.
Topics of interest include:
1) Novel mechanisms underlying the involvement of cell receptors in CVDs.
2) Interactions between cell receptors and their signaling pathways in the cardiovascular system and other organs.
3) Update on the use of drugs targeting receptors in the prevention and treatment of CVDs.
4) Studies that provide future research to promote our knowledge in the research area of CVDs and receptors.
