Bone metastases are common in many cancers and associated with skeletal-related events such as spinal cord compression, fractures, pain, disability, and impaired quality of life. Bone metastasis is most prominent in breast, prostate, and lung cancer patients and is the leading cause of cancer-associated death. Osteoblasts and osteoclasts control each other’s functions to maintain normal bone homeostasis. In addition, bone remodeling is governed by the balanced activity of the bone and immune cells. Bone metastasis is a multistage process, and the bone microenvironment influences the seeding and colonization of the disseminated cancer cells. Disruption of bone homeostasis and immune population provides fertile soil to facilitate cancer cell seeding. Despite the advancement of our understanding to treat primary tumors, most of the treatments for bone metastasis are palliative. Proper understanding of the immune component of the bone and their involvement in bone metastasis niche formation will help to explore future directions of bone metastasis research.
We are pleased to invite the researchers working on cancer and metastasis to contribute to the special issue. We aimed to gather the Original research article, Review, Mini-Review, Focused Review, Protocol, Method, Perspective, and Opinion articles. The current research topic will cover the following mentioned articles that contribute to the major advancement of bone metastasis in osteoimmunology.
1. Osteoimmunology in bone metastases
2. Bone and immune cells in tumor dormancy
3. Targeted therapies for bone metastasis
4. Single-cell immune profiling for bone metastasis
5. Osteoimmunological alteration in Premetastatic Niche formation
6. Hematopoietic and mesenchymal niche in bone metastasis
7. Microbiota and bone metastasis
8. Osteoimmunology and Therapy resistance
Bone metastases are common in many cancers and associated with skeletal-related events such as spinal cord compression, fractures, pain, disability, and impaired quality of life. Bone metastasis is most prominent in breast, prostate, and lung cancer patients and is the leading cause of cancer-associated death. Osteoblasts and osteoclasts control each other’s functions to maintain normal bone homeostasis. In addition, bone remodeling is governed by the balanced activity of the bone and immune cells. Bone metastasis is a multistage process, and the bone microenvironment influences the seeding and colonization of the disseminated cancer cells. Disruption of bone homeostasis and immune population provides fertile soil to facilitate cancer cell seeding. Despite the advancement of our understanding to treat primary tumors, most of the treatments for bone metastasis are palliative. Proper understanding of the immune component of the bone and their involvement in bone metastasis niche formation will help to explore future directions of bone metastasis research.
We are pleased to invite the researchers working on cancer and metastasis to contribute to the special issue. We aimed to gather the Original research article, Review, Mini-Review, Focused Review, Protocol, Method, Perspective, and Opinion articles. The current research topic will cover the following mentioned articles that contribute to the major advancement of bone metastasis in osteoimmunology.
1. Osteoimmunology in bone metastases
2. Bone and immune cells in tumor dormancy
3. Targeted therapies for bone metastasis
4. Single-cell immune profiling for bone metastasis
5. Osteoimmunological alteration in Premetastatic Niche formation
6. Hematopoietic and mesenchymal niche in bone metastasis
7. Microbiota and bone metastasis
8. Osteoimmunology and Therapy resistance
