Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases

Editorial

19 February 2016

Editorial: Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases

Mohammadreza Hajjari

Seyed Javad Mowla

and

Mohammad Ali Faghihi

3,204 views

4 citations

Editors

Seyed Javad Mowla

Tarbiat Modares University

Mohammadreza Hajjari

Shahid Chamran University of Ahvaz

Mohammad Faghihi

Express Gene Molecular Diagnostics Laboratory

Impact

Expression signature of SOX2OT and its correlations with other genes in human. (A,B) Approximate expression profiles of SOX2OT and SOX2 based on ESTs (dbEST) distribution in human tissues, and tumors libraries; the data is presented according to TPM (transcript per million) in pool. High enrichment of SOX2OT expression in CNS libraries and also brain-derived tumors is noticeable. (C) Two dimensional display of gene expression summary of SOX2OT SAGE expression represents positive and negative significant correlation with multiple key genes involved cancer progression, stem cell pluripotency, and development. The data was adopted from available SAGE libraries of the cancer genome anatomy project database [Cancer Genome Anatomy Project (CGAP)] (http://cgap.nci.nih.gov). Ten positively correlated genes (R > 0.9 top of map) and 10 negatively correlated ones (R < –0.35, bottom of map) are listed (P: P value, R: correlation value).

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17 June 2015

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The multifaceted action of the lncRNA H19. The lncRNA H19 controls genome expression at multiple levels. H19 acts on chromatin organization through the recruitment of chromatin modifying complex PRC2 (1) and on post-transcriptional control as a miR decoys sequestering miR-106a and miR-let7 (2) or as a precursor for miR-675-5p and miR-675-3p (3) H19 also interact with p53 (TP53) and inactivate the tumor suppressor protein action (4) Furthermore, possible base pairing between H19 and the antisense transcripts 91H and HOTS may have biological outcomes (5).

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, 2 more and

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Open for submission

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