The intestine is an important mucosal immune organ of the body that plays a central role in the innate and acquired immunity of teleosts. It is well known that fish intestines are often exposed to a large and diverse assortment of bacterial, viral, and parasitic pathogens that can cause significant intestinal inflammation and challenge the health status of the fish. Additionally, some diets, such as high soybean meal (SBM), fed to fish have been shown to cause an inflammatory response in the intestine of various farmed fish species. Under intensive rearing conditions, intestinal inflammation is emerging as a major cause of high mortality in farmed fish, causing huge economic losses. However, the exact molecular mechanisms of intestinal inflammation are still not well understood in bony fish.
To understand the mechanisms of intestinal inflammation, several experimental models have been created in fish. Previous studies showed that fish models of intestinal inflammation will not only extend our understanding in pathological mechanisms involved in intestinal inflammation of teleost fish but also provide a tool to screen novel drugs for the treatment of inflammatory diseases in aquacultural animals. Up to now, fish models of intestinal inflammation are still fairly scarce though dozens of such models have been established in mammals. In the process of traditional aquaculture, chemical drugs or antibiotics have been widely used for the prevention or treatment of fish enteritis, which leads to environmental pollution and food safety problems. Nutrition intervention is an effective and environment-friendly way to prevent the development of intestinal inflammation and promote sustainable aquaculture development.
The aim of this Research Topic is to gather new research in the field of molecular mechanism and nutritional intervention of intestinal inflammation in Fish, including pathogenesis, experimental models, and nutrition intervention approaches of intestinal inflammation. The approval and successful implementation of this Research Topic will not only contribute to understanding the molecular mechanisms of intestinal inflammation but also provide new insights into a nutritional intervention on prevention and control of fish enteritis. We welcome manuscripts from the following subtopics:
• Pathogenesis of intestinal inflammation in fish
• Nutrition intervention of intestinal inflammation in fish
• Functional characterization of the intestinal inflammation-related pathway in fish
• Transcriptome and proteome analysis of intestinal inflammation in fish
• Developing experimental models of intestinal inflammation in fish
The intestine is an important mucosal immune organ of the body that plays a central role in the innate and acquired immunity of teleosts. It is well known that fish intestines are often exposed to a large and diverse assortment of bacterial, viral, and parasitic pathogens that can cause significant intestinal inflammation and challenge the health status of the fish. Additionally, some diets, such as high soybean meal (SBM), fed to fish have been shown to cause an inflammatory response in the intestine of various farmed fish species. Under intensive rearing conditions, intestinal inflammation is emerging as a major cause of high mortality in farmed fish, causing huge economic losses. However, the exact molecular mechanisms of intestinal inflammation are still not well understood in bony fish.
To understand the mechanisms of intestinal inflammation, several experimental models have been created in fish. Previous studies showed that fish models of intestinal inflammation will not only extend our understanding in pathological mechanisms involved in intestinal inflammation of teleost fish but also provide a tool to screen novel drugs for the treatment of inflammatory diseases in aquacultural animals. Up to now, fish models of intestinal inflammation are still fairly scarce though dozens of such models have been established in mammals. In the process of traditional aquaculture, chemical drugs or antibiotics have been widely used for the prevention or treatment of fish enteritis, which leads to environmental pollution and food safety problems. Nutrition intervention is an effective and environment-friendly way to prevent the development of intestinal inflammation and promote sustainable aquaculture development.
The aim of this Research Topic is to gather new research in the field of molecular mechanism and nutritional intervention of intestinal inflammation in Fish, including pathogenesis, experimental models, and nutrition intervention approaches of intestinal inflammation. The approval and successful implementation of this Research Topic will not only contribute to understanding the molecular mechanisms of intestinal inflammation but also provide new insights into a nutritional intervention on prevention and control of fish enteritis. We welcome manuscripts from the following subtopics:
• Pathogenesis of intestinal inflammation in fish
• Nutrition intervention of intestinal inflammation in fish
• Functional characterization of the intestinal inflammation-related pathway in fish
• Transcriptome and proteome analysis of intestinal inflammation in fish
• Developing experimental models of intestinal inflammation in fish