Until now, treatment of most movement disorders is based on pharmacological treatment. For example, dopamine replacement treatment is still the gold standard for managing Parkinson's disease. However, there are also many refractory symptoms to dopaminergic treatment such as freezing of gait, intractable tremor, and most non-motor symptoms in Parkinson's disease. Therefore, exploring effective alternative treatment options is still urgent and necessary. Recently, many kinds of non-pharmacological treatment in movement disorders are emerging including exercise, non-invasive brain stimulation, and deep brain stimulation. However, it still remains to be elucidated, the exact mechanisms and solid evidences for these treatment modalities.
In this topic, we aim to encompass state of the art research and review ranging from basic neuroscience to clinical trials which investigates mechanism and efficacy of non-pharmacological treatment in movement disorders, which could expand our understanding and possibility of treating patients. Also, this topic intends to facilitate summarize current evidence of non-pharmacologic treatment of movement disorders. This effort might incorporate underrated effective treatment modality into guideline of treatment and prevent unnecessary treatment from patients. Consequently, we could contribute to the development of new ways of helping patients suffering from various movement disorders.
Non-pharmacological treatment in this topic includes any modality beyond pharmacological intervention including physical therapy (Exercise, rehabilitation, intervention), computer based training, alternative medicine (herbal medicine, acupuncture, natural product), surgical intervention (deep brain stimulation, focused ultrasound stimulation, pallidotomy), non-invasive brain stimulation (transcranial magnetic stimulation, transcranial direct current stimulation) and other experimental procedures. Although clinical trials and study for elucidating mechanism or efficacy of treatment modality are preferred, all kinds of research could be allowed including epidemiology, basic research animal, and biomarker studies.
Until now, treatment of most movement disorders is based on pharmacological treatment. For example, dopamine replacement treatment is still the gold standard for managing Parkinson's disease. However, there are also many refractory symptoms to dopaminergic treatment such as freezing of gait, intractable tremor, and most non-motor symptoms in Parkinson's disease. Therefore, exploring effective alternative treatment options is still urgent and necessary. Recently, many kinds of non-pharmacological treatment in movement disorders are emerging including exercise, non-invasive brain stimulation, and deep brain stimulation. However, it still remains to be elucidated, the exact mechanisms and solid evidences for these treatment modalities.
In this topic, we aim to encompass state of the art research and review ranging from basic neuroscience to clinical trials which investigates mechanism and efficacy of non-pharmacological treatment in movement disorders, which could expand our understanding and possibility of treating patients. Also, this topic intends to facilitate summarize current evidence of non-pharmacologic treatment of movement disorders. This effort might incorporate underrated effective treatment modality into guideline of treatment and prevent unnecessary treatment from patients. Consequently, we could contribute to the development of new ways of helping patients suffering from various movement disorders.
Non-pharmacological treatment in this topic includes any modality beyond pharmacological intervention including physical therapy (Exercise, rehabilitation, intervention), computer based training, alternative medicine (herbal medicine, acupuncture, natural product), surgical intervention (deep brain stimulation, focused ultrasound stimulation, pallidotomy), non-invasive brain stimulation (transcranial magnetic stimulation, transcranial direct current stimulation) and other experimental procedures. Although clinical trials and study for elucidating mechanism or efficacy of treatment modality are preferred, all kinds of research could be allowed including epidemiology, basic research animal, and biomarker studies.