Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent studies have provided sufficient evidence that CVD may be also attributed to microbiota, especially the gut microbiome. The gut microbiota can produce bioactive metabolites, including trimethylamine-N-oxide (TMAO), uremic toxins, short-chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide, which are also involved in host health and disease via numerous pathways. Thus, the gut microbiota and its metabolic pathways have attracted growing attention as a therapeutic target for CVD treatment. In addition to microbiota in the gut, microbiota from other parts of the body, such as oral bacteria, also plays a role in the pathogenesis of CVD. Therefore, considering the rapid expansion between the microbiome and CVD field, we propose this Research Topic to bring increased awareness to the diverse effect of the microbiota on human health and disease in addition to the gut microbiome.
This Research Topic is focused on the complex interplay between microbiota, their metabolites, and the potential influence on the generation and development of cardiovascular diseases, which might explore novel therapeutic strategies for directly targeting microbiome, their metabolites, or related signaling pathways to improve cardiovascular outcomes.
The objective of this Research Topic is to collate a series of reviews, commentaries, and research articles on the effect of the microbiota in various cardiovascular disease settings including, but not limited to, atherosclerosis, atherosclerosis, coronary artery disease, myocardial infarction, hypertension, heart failure, atrial fibrillation, and myocarditis. Moreover, understanding the pathogenesis of CVD at the molecular level from the aspect of microbiota and their metabolites is one of our interests. These will include, but are not limited to, the following fields:
• Experimental medicine
• Immunity
• Internal medicine
• Metabolism
• Genetics
Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent studies have provided sufficient evidence that CVD may be also attributed to microbiota, especially the gut microbiome. The gut microbiota can produce bioactive metabolites, including trimethylamine-N-oxide (TMAO), uremic toxins, short-chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide, which are also involved in host health and disease via numerous pathways. Thus, the gut microbiota and its metabolic pathways have attracted growing attention as a therapeutic target for CVD treatment. In addition to microbiota in the gut, microbiota from other parts of the body, such as oral bacteria, also plays a role in the pathogenesis of CVD. Therefore, considering the rapid expansion between the microbiome and CVD field, we propose this Research Topic to bring increased awareness to the diverse effect of the microbiota on human health and disease in addition to the gut microbiome.
This Research Topic is focused on the complex interplay between microbiota, their metabolites, and the potential influence on the generation and development of cardiovascular diseases, which might explore novel therapeutic strategies for directly targeting microbiome, their metabolites, or related signaling pathways to improve cardiovascular outcomes.
The objective of this Research Topic is to collate a series of reviews, commentaries, and research articles on the effect of the microbiota in various cardiovascular disease settings including, but not limited to, atherosclerosis, atherosclerosis, coronary artery disease, myocardial infarction, hypertension, heart failure, atrial fibrillation, and myocarditis. Moreover, understanding the pathogenesis of CVD at the molecular level from the aspect of microbiota and their metabolites is one of our interests. These will include, but are not limited to, the following fields:
• Experimental medicine
• Immunity
• Internal medicine
• Metabolism
• Genetics