Extracellular vesicles are a group of nanosized membrane-bound vesicles including exosomes, macrovesicle and apoptotic bodies secreted by almost all types of cells. A variety of bioactive materials, including DNA, mRNA, non-coding RNAs, proteins, lipids, and cytokines are carried by extracellular vesicles, and therefore they are promising for tissue repairing. However, the properties of natural exosomes such as cell-targeting ability, biodistribution profiles and pharmacokinetics are limited, and could be further improved to achieve better therapeutic effects.
In recent years, bioengineering has emerged as a promising modality to improve the therapeutic potentials of extracellular vesicles. Alterations and improvement in biological, physical and chemical properties of extracellular vesicles are achieved by technological advances. Precision diagnosis of tissue injury could be achieved by specific trace to the lesions, and targeted therapy by accurate delivery with the loading of drugs becomes possible.
In this Research Topic, we aim to highlight recent advances in the exploration and application of engineered extracellular vesicles for tissue repairing and regeneration. This Research Topic would provide an overview on the effects and mechanisms of engineered extracellular vesicles for enhancing the therapeutic effects.
Submissions including original research, letter, and review articles are welcomed for this Research Topic. Articles are encouraged to cover, but are not limited to, the following areas:
-Engineering strategies, including indirect methods for donor cells and direct modifications (e.g., aptamer, folic acid, hyaluronic acid, magnetic nanoparticles, etc.) for extracellular vesicles.
-The efficacy and mechanisms of engineered extracellular vesicles for drug delivery.
-Application of engineered extracellular vesicles in the diagnosis and targeted therapy of tissue injury.
-Biomechanical and physiochemical properties of engineered extracellular vesicles.
Extracellular vesicles are a group of nanosized membrane-bound vesicles including exosomes, macrovesicle and apoptotic bodies secreted by almost all types of cells. A variety of bioactive materials, including DNA, mRNA, non-coding RNAs, proteins, lipids, and cytokines are carried by extracellular vesicles, and therefore they are promising for tissue repairing. However, the properties of natural exosomes such as cell-targeting ability, biodistribution profiles and pharmacokinetics are limited, and could be further improved to achieve better therapeutic effects.
In recent years, bioengineering has emerged as a promising modality to improve the therapeutic potentials of extracellular vesicles. Alterations and improvement in biological, physical and chemical properties of extracellular vesicles are achieved by technological advances. Precision diagnosis of tissue injury could be achieved by specific trace to the lesions, and targeted therapy by accurate delivery with the loading of drugs becomes possible.
In this Research Topic, we aim to highlight recent advances in the exploration and application of engineered extracellular vesicles for tissue repairing and regeneration. This Research Topic would provide an overview on the effects and mechanisms of engineered extracellular vesicles for enhancing the therapeutic effects.
Submissions including original research, letter, and review articles are welcomed for this Research Topic. Articles are encouraged to cover, but are not limited to, the following areas:
-Engineering strategies, including indirect methods for donor cells and direct modifications (e.g., aptamer, folic acid, hyaluronic acid, magnetic nanoparticles, etc.) for extracellular vesicles.
-The efficacy and mechanisms of engineered extracellular vesicles for drug delivery.
-Application of engineered extracellular vesicles in the diagnosis and targeted therapy of tissue injury.
-Biomechanical and physiochemical properties of engineered extracellular vesicles.