Ferroptosis in Cancer and Beyond

171K

views

214

authors

34

articles

Ferroptosis in Cancer and Beyond

171K

views

214

authors

34

articles

Editorial

04 January 2023

Editorial: Ferroptosis in cancer and beyond

Xin Wang

,

Guo Chen

,

Chaoyun Pan

and

Yanqing Liu

1,314 views

0 citations

Editors

4

Yanqing Liu

Columbia University

Guo Chen

China Pharmaceutical University

Chaoyun Pan

Sun Yat-sen University

Xin Wang

National Institutes of Health (NIH)

Impact

Fetching...

About

Ferroptosis, a newly identified type of regulated cell death, is caused by the unchecked oxidative perturbation within the cell. Since its discovery, ferroptosis has gained substantial attention in both basic research and clinical applications. Ferroptosis is associated with a variety of physiological or pathological processes, such as normal development, ischemic injuries, degenerative diseases, immune system activities, and remarkably is also involved in tumor biology. The physio-pathological relevance of ferroptosis makes it an attractive therapeutic target to cure different diseases. Numerous cellular factors and potential regulatory pathways underlying ferroptosis have been elucidated. However, new mechanisms and clinical relevance of ferroptosis are still emerging.

The aim of this Research Topic is to report on the basic mechanisms underlying ferroptosis, how ferroptosis is regulated, and how ferroptosis pathways can be targeted therapeutically. We will pay extra attention to these papers about novel/non-canonical ferroptosis pathways. We also expect research identifying existing or new drugs that target the ferroptosis pathway in diverse diseases, particularly tumors.

Original Research Articles, Reviews, and Mini-Reviews are welcome to submit to this Research Topic. Papers are expected to cover but are not limited to the following topics:

(1) Basic mechanism and novel regulators of ferroptosis.

(2) Role of p53 in both canonical and non-canonical ferroptosis regulation.

(3) Targeting ferroptosis for disease (including tumor, neurodegenerative diseases, ischemic organ injury, dysregulated cell oxidative response, and immune cell function) treatment.

Please note that the findings based on bioinformatic data mining should be better validated by experiments.

Download ebook

PDF

EPUB

Share

Editors

Yanqing Liu

Columbia University

Guo Chen

China Pharmaceutical University

Chaoyun Pan

Sun Yat-sen University

Xin Wang

National Institutes of Health (NIH)

Impact

171,000 Total views

108,689 Article views

58,915 Article downloads

3,396 Topic views

Published In

Frontiers in Molecular Biosciences

Molecular Diagnostics and Therapeutics

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic