Virus infection has been developing with human development. Hepatitis B virus (HBV) infection remains a threat to global health, which affects 257 million people worldwide according to the 2017 Global Hepatitis Report of WHO, although the hepatitis B vaccine has been popularized for decades. Chronic HBV infection could progress into liver cirrhosis, hepatocellular carcinoma (HCC), and even liver failure if the patients could not be treated effectively and timely. It is well known that immune cells and immune molecules play a vital role in the anti-infection immunity of the host, which can bring into full play cellular and humoral immune function to wipe out viral infection in the host. Additionally, the occurrence and development of chronic HBV infection are closely associated with an imbalance of immune function in the host, and the immune internal environment, including intestinal microbiota, also plays an important role in disease development and control.
Further understanding of the relationship between hepatitis B virus (HBV), intestinal microbiota, and host immune response, and recognizing the interrelationship among the three subjects, could provide important data for the diagnosis, treatment, and even development of the vaccine for HBV infection. We are looking for articles (Original Research, Reviews, Mini-Reviews, Perspectives, Brief Research Reports, oriented to basic and translational biology), covering various aspects in the cellular and molecular immunology of HBV-related diseases that shed light on potential pathobiological mechanisms. The topics are but not limited to the followings:
• Profiling changes of immune cells, immune molecule, and immunological function of host infected with hepatitis B virus, including congenital infection, and being subjected to treatment (medicine and biological, physical treatment (including artificial liver support system))
• Screening therapeutic applications of all known and new emerging cytokines, cytotoxins, interferons, chemokines, adipokines, hematopoietic factors, and growth factors in subjects of viral infection
• Research into various omics (genomics, transcriptomics, metabolomics, and immune repertoire (T cell receptor, B cell receptor)) related to HBV infection by using high-throughput sequencing, bioinformatics analysis technology, and online database
• Studies reporting all signaling molecules from the pathogens and host-endogenous sources, metabolic products/adducts that mediate inflammation and immunity
• Immunological mechanisms of HBV infection and chronic progression, the mechanisms of positive and negative (weak) responders to specificity vaccines
• Effect of the internal environment including intestinal microbiota on host immune response to HBV infection
Virus infection has been developing with human development. Hepatitis B virus (HBV) infection remains a threat to global health, which affects 257 million people worldwide according to the 2017 Global Hepatitis Report of WHO, although the hepatitis B vaccine has been popularized for decades. Chronic HBV infection could progress into liver cirrhosis, hepatocellular carcinoma (HCC), and even liver failure if the patients could not be treated effectively and timely. It is well known that immune cells and immune molecules play a vital role in the anti-infection immunity of the host, which can bring into full play cellular and humoral immune function to wipe out viral infection in the host. Additionally, the occurrence and development of chronic HBV infection are closely associated with an imbalance of immune function in the host, and the immune internal environment, including intestinal microbiota, also plays an important role in disease development and control.
Further understanding of the relationship between hepatitis B virus (HBV), intestinal microbiota, and host immune response, and recognizing the interrelationship among the three subjects, could provide important data for the diagnosis, treatment, and even development of the vaccine for HBV infection. We are looking for articles (Original Research, Reviews, Mini-Reviews, Perspectives, Brief Research Reports, oriented to basic and translational biology), covering various aspects in the cellular and molecular immunology of HBV-related diseases that shed light on potential pathobiological mechanisms. The topics are but not limited to the followings:
• Profiling changes of immune cells, immune molecule, and immunological function of host infected with hepatitis B virus, including congenital infection, and being subjected to treatment (medicine and biological, physical treatment (including artificial liver support system))
• Screening therapeutic applications of all known and new emerging cytokines, cytotoxins, interferons, chemokines, adipokines, hematopoietic factors, and growth factors in subjects of viral infection
• Research into various omics (genomics, transcriptomics, metabolomics, and immune repertoire (T cell receptor, B cell receptor)) related to HBV infection by using high-throughput sequencing, bioinformatics analysis technology, and online database
• Studies reporting all signaling molecules from the pathogens and host-endogenous sources, metabolic products/adducts that mediate inflammation and immunity
• Immunological mechanisms of HBV infection and chronic progression, the mechanisms of positive and negative (weak) responders to specificity vaccines
• Effect of the internal environment including intestinal microbiota on host immune response to HBV infection