Organ transplantation is one of the most outstanding achievements of modern medicine, saving lives. At the same time, the development of human organ transplantation technology brings hope to the treatment of various diseases. However, the biggest problem facing organ transplantation is the severe shortage of donor organs. Currently, donor donation, Xenotransplantation, organid, 3D printing and other projects are expected to solve this problem. However, there are still many problems to be solved in these technologies' research and clinical application. For example, interspecies chimaeras have only been successfully achieved in rats and mice despite their great potential. The low chimerism efficiency of human pluripotent stem cells in animal embryos may be attributed to imperfect culture, evolutionary distance and developmental incompatibility of pluripotent stem cells.
There are still many problems to be solved in this field. This Research Topic plans to provide an overview of the most recent advances in the field of organ transplantation. It aims to investigate advances in Xenotransplantation, blastocyst complementation, strategies to improve interspecies chimaeras' efficiency, and Xenotransplantation ethics. In addition, the construction method of different kinds of organoids and the immune rejection after transplantation are also widely concerned.
Areas to be covered may include, but are not limited to:
• Xenotransplantation
• Blastocyst complementation
• Construction and application of organoid
• Pedigree tracing
• Critical genes of organ formation
• Overcoming immune rejection
• Ethics of Xenotransplantation
Organ transplantation is one of the most outstanding achievements of modern medicine, saving lives. At the same time, the development of human organ transplantation technology brings hope to the treatment of various diseases. However, the biggest problem facing organ transplantation is the severe shortage of donor organs. Currently, donor donation, Xenotransplantation, organid, 3D printing and other projects are expected to solve this problem. However, there are still many problems to be solved in these technologies' research and clinical application. For example, interspecies chimaeras have only been successfully achieved in rats and mice despite their great potential. The low chimerism efficiency of human pluripotent stem cells in animal embryos may be attributed to imperfect culture, evolutionary distance and developmental incompatibility of pluripotent stem cells.
There are still many problems to be solved in this field. This Research Topic plans to provide an overview of the most recent advances in the field of organ transplantation. It aims to investigate advances in Xenotransplantation, blastocyst complementation, strategies to improve interspecies chimaeras' efficiency, and Xenotransplantation ethics. In addition, the construction method of different kinds of organoids and the immune rejection after transplantation are also widely concerned.
Areas to be covered may include, but are not limited to:
• Xenotransplantation
• Blastocyst complementation
• Construction and application of organoid
• Pedigree tracing
• Critical genes of organ formation
• Overcoming immune rejection
• Ethics of Xenotransplantation
