Regulation of protein kinase signaling in cardiovascular disease

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Friederike Cuello

University Medical Center Hamburg-Eppendorf

Kristina Lorenz

Julius Maximilian University of Würzburg

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The human genome contains about 500 protein kinase genes. Protein kinases modify an estimated 30% of the human proteome and thus regulate the majority of cellular transduction pathways. In the cardiovascular system, altered protein kinase signalling is increasingly recognized as a key driver of disease development. Recent advances unravelling structure-function-relationships, regulatory mechanisms and physiological roles of protein kinases, renders them attractive targets for the development of novel treatment strategies. These strategies include the interference with protein kinase activity in general or more specifically target disease-specific kinase functions by regulating spatial-temporal distribution, protein-protein interactions and their subcellular localization.

This research topic aims to provide an overview of the key protein kinases implicated in cardiovascular disease and their regulatory mechanisms including other protein kinases, protein phosphatases, scaffold proteins and the redox system of the cell.

The human genome contains about 500 protein kinase genes. Protein kinases modify an estimated 30% of the human proteome and thus regulate the majority of cellular transduction pathways. In the cardiovascular system, altered protein kinase signalling is increasingly recognized as a key driver of disease development. Recent advances unravelling structure-function-relationships, regulatory mechanisms and physiological roles of protein kinases, renders them attractive targets for the development of novel treatment strategies. These strategies include the interference with protein kinase activity in general or more specifically target disease-specific kinase functions by regulating spatial-temporal distribution, protein-protein interactions and their subcellular localization.

This research topic aims to provide an overview of the key protein kinases implicated in cardiovascular disease and their regulatory mechanisms including other protein kinases, protein phosphatases, scaffold proteins and the redox system of the cell.

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Editors

Friederike Cuello

University Medical Center Hamburg-Eppendorf

Kristina Lorenz

Julius Maximilian University of Würzburg

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Frontiers in Pharmacology

Cardiovascular and Smooth Muscle Pharmacology

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