The Role of Angiogenesis and Immune Response in Tumor Microenvironment of Solid Tumor

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Editorial

18 April 2023

Editorial: The role of angiogenesis and immune response in tumor microenvironment of solid tumor

Zichao Guo

,

Yimei Jiang

,

Baochi Ou

,

Xin Lu

, 1 more and

Ren Zhao

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4

Ren Zhao

Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University

Xi Cheng

Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University

Xin Lu

University of Notre Dame

Baochi Ou

First Affiliated Hospital of Anhui Medical University

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The microenvironment of tumors is consisted of the tumor stroma, proliferating tumor cells, infiltrating inflammatory cells, blood vessels, and various associated tissue cells. The pre-metastatic niche (PRN) is described as supportive and receptive, which undergoes cellular and molecular changes to form the fertile “soil” or metastatic-designated sites for metastatic tumor cell “seed” colonization. Thus, the PRN supports promoting tumor metastasis and tumor settlement in distant organs. The infiltration of the immune cells and the formation of blood vessels from the pre-metastatic sites are critical for the tumor microenvironment. Typically, the angiogenic factor is strongly associated with the inflammatory response during the development of tumors. Additionally, the immunoediting processes are essentially devoted to promoting angiogenesis and modulating the innate and specific immune responses.

In this research topic, we would like to share new findings and discussions on the role of angiogenesis and immune response in the tumor microenvironment of solid tumors. We welcome Review, Original Research, and Method articles in the following subtopics:

1) Novel mechanisms or targets connected with immune response and angiogenesis in solid tumors.
2) Tumor variation of angiogenesis and immune system.
3) Therapeutic advances impacting the immune system and angiogenesis in solid tumors.
4) Association of tumor-infiltrating immune cells on cancer.
5) Influence of anti-angiogenic normalization that advances the evolution of the immune system.

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Editors

Ren Zhao

Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University

Xi Cheng

Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University

Xin Lu

University of Notre Dame

Baochi Ou

First Affiliated Hospital of Anhui Medical University

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Published In

Frontiers in Immunology

Cancer Immunity and Immunotherapy

Frontiers in Oncology

Cancer Immunity and Immunotherapy

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