The development of the cerebral cortex relies on an exquisitely timed coordination of cell proliferation, differentiation, migration, and organization. Disruption of this process, either by genetic or environmental processes, can create a disorder of cerebral development and cause neurodevelopmental impairment such as intellectual disability, cerebral palsy, and epilepsy.
In recent decades, the genetic basis for many of these disorders has been unveiled, guiding management, improving genetic counseling, providing pathophysiological insights, and aiding the development of specific treatments. However, imaging, clinical outcomes, and genetic basis remain very heterogeneous among neurodevelopmental disorders presenting with malformations of cortical development. Furthermore, many disorders remain poorly characterized, and imaging-phenotype, as well as genotype-phenotype correlations, are challenging.
The overall goal of this Research Topic is to:
- provide an overview of the clinical, radiological, and pathophysiologic characterization of malformations of cortical development
- update on the genetic basis
- update of the recent understanding of the pathophysiologic basis
- recognition of imaging patterns of cortical malformation
- correlation of imaging and genetic findings with clinical outcomes
- optimization of treatments
Scope and information for authors include:
- expansion of phenotypes
- clinical, radiologic, and genetic characterization of cohorts
- genotype-phenotype correlations
- neurophysiological and imaging studies
- studies providing insight into underlying pathophysiological
- functional characterization of novel variants
We welcome submissions of Perspectives, Original Research, Systematic Reviews, Mini Reviews, Brief Research Reports, Case Reports and General Commentaries.
The development of the cerebral cortex relies on an exquisitely timed coordination of cell proliferation, differentiation, migration, and organization. Disruption of this process, either by genetic or environmental processes, can create a disorder of cerebral development and cause neurodevelopmental impairment such as intellectual disability, cerebral palsy, and epilepsy.
In recent decades, the genetic basis for many of these disorders has been unveiled, guiding management, improving genetic counseling, providing pathophysiological insights, and aiding the development of specific treatments. However, imaging, clinical outcomes, and genetic basis remain very heterogeneous among neurodevelopmental disorders presenting with malformations of cortical development. Furthermore, many disorders remain poorly characterized, and imaging-phenotype, as well as genotype-phenotype correlations, are challenging.
The overall goal of this Research Topic is to:
- provide an overview of the clinical, radiological, and pathophysiologic characterization of malformations of cortical development
- update on the genetic basis
- update of the recent understanding of the pathophysiologic basis
- recognition of imaging patterns of cortical malformation
- correlation of imaging and genetic findings with clinical outcomes
- optimization of treatments
Scope and information for authors include:
- expansion of phenotypes
- clinical, radiologic, and genetic characterization of cohorts
- genotype-phenotype correlations
- neurophysiological and imaging studies
- studies providing insight into underlying pathophysiological
- functional characterization of novel variants
We welcome submissions of Perspectives, Original Research, Systematic Reviews, Mini Reviews, Brief Research Reports, Case Reports and General Commentaries.