Bones represent a mirror that reflects a plethora of metabolic and endocrine processes. Hence, skeletal fragility and osteoporosis, caused by disturbed bone metabolism, is observed in many endocrinopathies, such as hypogonadism, hyperparathyroidism, adrenal, pituitary, or thyroid diseases. Looking for secondary reasons of osteoporosis is especially important in males and young patients, since treatment of hormone excess and deficiency generally improves skeletal health. Such an approach would provide an opportunity to demonstrate the multidisciplinary nature of bone metabolic disorders in relation to clinical endocrinology.
In this Research Topic we have therefore endeavor to address the impact of multiple endocrine/metabolic abnormalities in relation to secondary osteoporosis in aspect of different reasons of that state including diseases of pituitary, adrenals, thyroid, parathyroids, and vitamin D disturbances. Their effect on fracture risk, bone quality and bone quantity (including bone densitometry), and bone markers will be discussed. Possible relationship to other factors that influence bone metabolism as well as calcium/phosphate balance, such as sclerostin, FGF-23, etc., can be also analyzed. In such a way, we will outline the multitude of factors that influence bone health in humans.
The aim of this Research Topic is to discuss the physiological, pathophysiological, and clinical insights of bone involvement in endocrine diseases through the lens of osteoporosis. We welcome original research, reviews, mini reviews, perspective, and opinion articles. Themes of interest include the following:
• Bone metabolism & pituitary disease (hypopituitarism, Cushing disease, acromegaly, and hyperprolactinemia)
• Bone metabolism & sex hormone deficiency
• Bone metabolism & thyroid disease (hyper and hypothyroidism)
• Bone metabolism & adrenal disease (tumors, congenital adrenal hyperplasia)
• Bone metabolism & parathyroid disease (primary and secondary hyperparathyroidism,
normocalcemic hyperparathyroidism)
Bones represent a mirror that reflects a plethora of metabolic and endocrine processes. Hence, skeletal fragility and osteoporosis, caused by disturbed bone metabolism, is observed in many endocrinopathies, such as hypogonadism, hyperparathyroidism, adrenal, pituitary, or thyroid diseases. Looking for secondary reasons of osteoporosis is especially important in males and young patients, since treatment of hormone excess and deficiency generally improves skeletal health. Such an approach would provide an opportunity to demonstrate the multidisciplinary nature of bone metabolic disorders in relation to clinical endocrinology.
In this Research Topic we have therefore endeavor to address the impact of multiple endocrine/metabolic abnormalities in relation to secondary osteoporosis in aspect of different reasons of that state including diseases of pituitary, adrenals, thyroid, parathyroids, and vitamin D disturbances. Their effect on fracture risk, bone quality and bone quantity (including bone densitometry), and bone markers will be discussed. Possible relationship to other factors that influence bone metabolism as well as calcium/phosphate balance, such as sclerostin, FGF-23, etc., can be also analyzed. In such a way, we will outline the multitude of factors that influence bone health in humans.
The aim of this Research Topic is to discuss the physiological, pathophysiological, and clinical insights of bone involvement in endocrine diseases through the lens of osteoporosis. We welcome original research, reviews, mini reviews, perspective, and opinion articles. Themes of interest include the following:
• Bone metabolism & pituitary disease (hypopituitarism, Cushing disease, acromegaly, and hyperprolactinemia)
• Bone metabolism & sex hormone deficiency
• Bone metabolism & thyroid disease (hyper and hypothyroidism)
• Bone metabolism & adrenal disease (tumors, congenital adrenal hyperplasia)
• Bone metabolism & parathyroid disease (primary and secondary hyperparathyroidism,
normocalcemic hyperparathyroidism)
