Understanding the acute and cumulative risk during impulsive loading to the human head remains a challenge in modern society. Such knowledge will be critical to define return to play criteria for competitive sports and militaries while providing improved guidance for front-line medical providers when triaging patients. “Dose-response” is a powerful framework to define injury and risk from exposures – yet a comprehensive method to place traumatic brain injury within such a framework is missing. Although there exist many efforts to link “exposure” of head trauma to a “response,” such approaches often fail to define “dose,” thus limiting reproducibility, extrapolation, and interpretation of results. But by harnessing the mathematical tools of engineering mechanics, “dose” can be quantified at a tissue level and such “doses” can then be linked to physiologic/neuropathologic “responses.”
The goal of this topic is to explore traumatic brain injury from a dose-response perspective. Specifically submitted work should aim to either link exposure to tissue-level quantified measurements of “dose”, and /or link controlled “dosing” to quantifiable changes in physiology or markers of cellular disruption. Ideally, investigations to this topic would provide tools or techniques to predict a quantifiable “dose” of brain trauma following an impulsive loading, or in vitro or in vivo experiments where tissue level “dose” was controlled and quantified when analyzing the “response.”
This topic will be interested in a broad range of investigations whereby a tissue-level “dose” of impulsive loading is measured, estimated, or controlled for. Preference will be given to investigations that quantifiably link “exposure” to “dose” or “dose” to “response.” Possible topics could include
1. Novel experimental methods to quantify tissue-level “dose” in in vivo subjects to impulsive loading.
2. Validated computational models used to predict tissue-level “dose” in experimental models of traumatic brain injury or clinically relevant exposures.
3. In vitro models exploring how controlled and quantified “doses” of impulsive loading lead to cellular or physiologic “responses”.
4. In vivo models of head trauma which predict tissue level “dosing” from exposure to analyze pathologic outcomes.
Topics that would not be of interest would include studies that do not quantify or correlate tissue “dose” following impulsive loading. Thus, cortical impacts or blast exposures that do not perform analysis to estimate the resultant brain tissue deformation would not be of interest to this topic. Furthermore, any computational model selected would require description and presentation of efforts to validate against experimental data.
Understanding the acute and cumulative risk during impulsive loading to the human head remains a challenge in modern society. Such knowledge will be critical to define return to play criteria for competitive sports and militaries while providing improved guidance for front-line medical providers when triaging patients. “Dose-response” is a powerful framework to define injury and risk from exposures – yet a comprehensive method to place traumatic brain injury within such a framework is missing. Although there exist many efforts to link “exposure” of head trauma to a “response,” such approaches often fail to define “dose,” thus limiting reproducibility, extrapolation, and interpretation of results. But by harnessing the mathematical tools of engineering mechanics, “dose” can be quantified at a tissue level and such “doses” can then be linked to physiologic/neuropathologic “responses.”
The goal of this topic is to explore traumatic brain injury from a dose-response perspective. Specifically submitted work should aim to either link exposure to tissue-level quantified measurements of “dose”, and /or link controlled “dosing” to quantifiable changes in physiology or markers of cellular disruption. Ideally, investigations to this topic would provide tools or techniques to predict a quantifiable “dose” of brain trauma following an impulsive loading, or in vitro or in vivo experiments where tissue level “dose” was controlled and quantified when analyzing the “response.”
This topic will be interested in a broad range of investigations whereby a tissue-level “dose” of impulsive loading is measured, estimated, or controlled for. Preference will be given to investigations that quantifiably link “exposure” to “dose” or “dose” to “response.” Possible topics could include
1. Novel experimental methods to quantify tissue-level “dose” in in vivo subjects to impulsive loading.
2. Validated computational models used to predict tissue-level “dose” in experimental models of traumatic brain injury or clinically relevant exposures.
3. In vitro models exploring how controlled and quantified “doses” of impulsive loading lead to cellular or physiologic “responses”.
4. In vivo models of head trauma which predict tissue level “dosing” from exposure to analyze pathologic outcomes.
Topics that would not be of interest would include studies that do not quantify or correlate tissue “dose” following impulsive loading. Thus, cortical impacts or blast exposures that do not perform analysis to estimate the resultant brain tissue deformation would not be of interest to this topic. Furthermore, any computational model selected would require description and presentation of efforts to validate against experimental data.