Emergence of multidrug resistant bacterial pathogens and decrease in effectiveness of antibiotics pose a global threat to public health. Preserving the efficacy of existing antibiotics minimizes the impact of resistance. Antibiotic potentiators offer such an alternative way to fill the growing gap between development and demand of new drugs.
Antibiotic adjuvants are non-antibiotic compounds that potentiate the activity of an antibiotic by blocking the function of resistance proteins or increasing membrane permeability or block biofilm formation. Such activities of adjuvants restore the antibiotic activity against resistant pathogens. Adjuvants are delivered together with the antibiotics. The goal of the proposed issue is to collect and published excellent original research articles and reviews covering the (i) Discovery and development of novel antibiotic potentiators
(ii) Microbial genome engineering for developing sensitive screening assay to identify antibiotic potentiators (iii) Computational screening and chemical analogues synthesis for new potentiators.
The scope of the proposed research topic includes original research articles and reviews with below the potential titles-
• Prevalence and genetic nature of acquired resistance in the critical and priority pathogens
• Diversity of antibiotic resistance mechanisms involving target modifications
• Antibiotic potentiators: Current status and future directions
• Mechanism of actions of antibiotic potentiators
• Natural and synthetic antibiotic potentiators in clinical practice
• Current status of potentiators against beta-lactam resistance
• Current status of potentiators against aminoglycoside resistance
• Current status of potentiators against macrolide resistance
• Current status of potentiators against peptide and glycopepeptide antibiotics
Emergence of multidrug resistant bacterial pathogens and decrease in effectiveness of antibiotics pose a global threat to public health. Preserving the efficacy of existing antibiotics minimizes the impact of resistance. Antibiotic potentiators offer such an alternative way to fill the growing gap between development and demand of new drugs.
Antibiotic adjuvants are non-antibiotic compounds that potentiate the activity of an antibiotic by blocking the function of resistance proteins or increasing membrane permeability or block biofilm formation. Such activities of adjuvants restore the antibiotic activity against resistant pathogens. Adjuvants are delivered together with the antibiotics. The goal of the proposed issue is to collect and published excellent original research articles and reviews covering the (i) Discovery and development of novel antibiotic potentiators
(ii) Microbial genome engineering for developing sensitive screening assay to identify antibiotic potentiators (iii) Computational screening and chemical analogues synthesis for new potentiators.
The scope of the proposed research topic includes original research articles and reviews with below the potential titles-
• Prevalence and genetic nature of acquired resistance in the critical and priority pathogens
• Diversity of antibiotic resistance mechanisms involving target modifications
• Antibiotic potentiators: Current status and future directions
• Mechanism of actions of antibiotic potentiators
• Natural and synthetic antibiotic potentiators in clinical practice
• Current status of potentiators against beta-lactam resistance
• Current status of potentiators against aminoglycoside resistance
• Current status of potentiators against macrolide resistance
• Current status of potentiators against peptide and glycopepeptide antibiotics
