Teasing apart and understanding the immunological microenvironment within neoplastic and inflammatory skin conditions is key for the development of new preventative and therapeutic treatment options. For example, research advances into the molecular interactions at play within melanoma have revolutionized immunotherapeutic treatment options by highlighting the importance of checkpoint inhibitor pathways including PD-1 and CTLA-4 in controlling T cell function. The outcomes of this basic research have led to clinical trials that have benefitted not just melanoma patients, but also patients with a wide array of other cancers, including less readily accessible cancer types. There is much that remains to be discovered in the field of skin immunology, particularly with respect to the immunological mechanisms that influence disease progression. In this topic series, we invite submissions that investigate immunological pathways and signaling molecules within neoplastic and inflammatory skin conditions including, but not limited to, skin cancers, autoimmunity, infection, burns, surgery, and immunologically mediated skin conditions.
The purpose of this Research Topic is to provide an up-to-date repository of research into the immunology of neoplastic and inflammatory skin conditions and diseases, with particular emphasis on potential new mechanisms of action.
We welcome experts in the fields of immunology and dermatology to submit original research articles and reviews describing and summarizing the latest insights into immune mechanisms of skin malignancies and other skin conditions.
• Skin inflammation: mechanisms, biomarkers, and therapies
• Soluble mediators and biomarkers of immunologically mediated skin conditions
• Promising combination therapies for the treatment of skin conditions
• Biomarkers of response to immunotherapy for skin cancer
• Interplay of epithelial and immune cells in skin disease
• Regulatory influences that promote the emergence of neoplastic or inflammatory disease
Teasing apart and understanding the immunological microenvironment within neoplastic and inflammatory skin conditions is key for the development of new preventative and therapeutic treatment options. For example, research advances into the molecular interactions at play within melanoma have revolutionized immunotherapeutic treatment options by highlighting the importance of checkpoint inhibitor pathways including PD-1 and CTLA-4 in controlling T cell function. The outcomes of this basic research have led to clinical trials that have benefitted not just melanoma patients, but also patients with a wide array of other cancers, including less readily accessible cancer types. There is much that remains to be discovered in the field of skin immunology, particularly with respect to the immunological mechanisms that influence disease progression. In this topic series, we invite submissions that investigate immunological pathways and signaling molecules within neoplastic and inflammatory skin conditions including, but not limited to, skin cancers, autoimmunity, infection, burns, surgery, and immunologically mediated skin conditions.
The purpose of this Research Topic is to provide an up-to-date repository of research into the immunology of neoplastic and inflammatory skin conditions and diseases, with particular emphasis on potential new mechanisms of action.
We welcome experts in the fields of immunology and dermatology to submit original research articles and reviews describing and summarizing the latest insights into immune mechanisms of skin malignancies and other skin conditions.
• Skin inflammation: mechanisms, biomarkers, and therapies
• Soluble mediators and biomarkers of immunologically mediated skin conditions
• Promising combination therapies for the treatment of skin conditions
• Biomarkers of response to immunotherapy for skin cancer
• Interplay of epithelial and immune cells in skin disease
• Regulatory influences that promote the emergence of neoplastic or inflammatory disease
