Gastrointestinal (GI) cancers, including esophageal, gastric, and colorectal cancers, are one of the major malignant diseases detrimental to health and account for almost 20% of all cancers worldwide. Besides their high incidence, GI cancers are related to high mortality rates, placing these malignancies among the most prominent public health issues of our time. Gastrointestinal diseases are prevalent, especially functional gastrointestinal disorders.
Natural product has been used for thousands of years in the treatment of gastrointestinal diseases including cancer. To discover and develop the natural product with therapeutic selectivity and without toxicity are very important steps in the treatment of GI diseases. Because of their wide range of pharmacologic activities and low toxicity in animal models, many natural products have been used as alternative treatments for gastrointestinal diseases and cancers.
Growing evidence has shown that natural products are beneficial for patients with gastrointestinal diseases or cancer, but it is still unconvincing and the mechanism behind the effect has not been fully revealed.
In this Research Topic, we emphasize:
(1) evaluation of clinical effectiveness of natural products in the treatment of gastrointestinal diseases including cancer; (2) mechanism of action of natural products; (3) translation of natural products into routine practice.
We invite researchers to contribute original research articles and review articles to explore natural products and the treatment of GI diseases including cancer. We are particularly interested in high-quality original research articles and systematic reviews focusing on gastric cancer, gastric ulcer, chronic gastritis, colorectal cancer, irritable bowel syndrome, constipation, functional dyspepsia, etc. Potential topics include, but are not limited to:
• Systematic reviews and meta-analyses evaluating the effectiveness of natural products.
• Randomized controlled trials, cohort studies, or real-world clinical studies evaluating the effectiveness of natural products.
• Experimental studies exploring the mechanism of action of natural products.
• Translational studies translate natural products to clinical practice based on clinical or animal study evidence.
Please note: Studies carried out with crude extracts/multiherbal preparations will not be considered for review. In contrast, studies that utilize highly purified, chemically characterized compounds meet the minimum criteria for the investigation of pharmacological effects. Where extracts are claimed to meet such minimum criteria, chemical structure and purity must be precisely described by appropriate analytical methods (e.g. chromatography and/or mass spectrometry).
Gastrointestinal (GI) cancers, including esophageal, gastric, and colorectal cancers, are one of the major malignant diseases detrimental to health and account for almost 20% of all cancers worldwide. Besides their high incidence, GI cancers are related to high mortality rates, placing these malignancies among the most prominent public health issues of our time. Gastrointestinal diseases are prevalent, especially functional gastrointestinal disorders.
Natural product has been used for thousands of years in the treatment of gastrointestinal diseases including cancer. To discover and develop the natural product with therapeutic selectivity and without toxicity are very important steps in the treatment of GI diseases. Because of their wide range of pharmacologic activities and low toxicity in animal models, many natural products have been used as alternative treatments for gastrointestinal diseases and cancers.
Growing evidence has shown that natural products are beneficial for patients with gastrointestinal diseases or cancer, but it is still unconvincing and the mechanism behind the effect has not been fully revealed.
In this Research Topic, we emphasize:
(1) evaluation of clinical effectiveness of natural products in the treatment of gastrointestinal diseases including cancer; (2) mechanism of action of natural products; (3) translation of natural products into routine practice.
We invite researchers to contribute original research articles and review articles to explore natural products and the treatment of GI diseases including cancer. We are particularly interested in high-quality original research articles and systematic reviews focusing on gastric cancer, gastric ulcer, chronic gastritis, colorectal cancer, irritable bowel syndrome, constipation, functional dyspepsia, etc. Potential topics include, but are not limited to:
• Systematic reviews and meta-analyses evaluating the effectiveness of natural products.
• Randomized controlled trials, cohort studies, or real-world clinical studies evaluating the effectiveness of natural products.
• Experimental studies exploring the mechanism of action of natural products.
• Translational studies translate natural products to clinical practice based on clinical or animal study evidence.
Please note: Studies carried out with crude extracts/multiherbal preparations will not be considered for review. In contrast, studies that utilize highly purified, chemically characterized compounds meet the minimum criteria for the investigation of pharmacological effects. Where extracts are claimed to meet such minimum criteria, chemical structure and purity must be precisely described by appropriate analytical methods (e.g. chromatography and/or mass spectrometry).
