Nature is a fertile source for providing promising secondary metabolites from plants, animal sources, marine organisms, and endophytes with potential biological activities. Scientists are in continuous search for natural anti-infective molecules to help alleviate simple and life-threatening ailments. The presence of antibiotic resistance by many microbes, their rising frequency and the ability of some microbes to develop biofilms, mandates the search for new antimicrobials which can be guided by evidence-based anti-infective effects reported by natural extracts, oils or their isolated components, which can modulate the antibiotic resistance and make the microbial infection become more liable for treatment. Incorporating natural products in a pharmaceutical form or the use of nanotechnology in formulating a delivery system of these natural anti-infective agents can ease and fasten their delivery to target organs.
Antimicrobial natural products can help overcome the problem of the continuous rise of resistant strains of bacteria, and fungi towards many drugs. In addition, natural compounds are relatively safe compared with their synthetic counterparts. Essential oils, natural extracts, fractions, and isolated pure compounds proved highly effective in tackling food-borne pathogens, urinary tract infection-causing bacteria and other human ailments related to microbial infection. Many potential antimicrobial therapeutics as efflux pump inhibitors and anti-biofilm agents have attracted researchers via unravelling their mechanistic approaches against bacterial pathogens. Nanotechnology has been extensively used to ensure the delivery of molecules to their target organs, minimize the dose, increase the bioavailability of the drug, and present a suitable pharmaceutical drug formulation. Nanotechnology scientists joined forces with natural products chemists to produce highly effective anti-infective agents. Biotechnology entered the race to produce highly effective anti-infective agents by the application of biotechnological principles for the production of anti-infective agents from fungi and bacteria.
Authors are encouraged to submit original research articles or reviews that include but are not limited to any of the following topics:
-Antimicrobial activity of natural products especially those containing polyphenols or terpenes.
-Presenting the molecular mechanism of action is highly recommended. Manuscripts testing the antimicrobial activity by measuring only the zone of inhibition will not be considered.
-Publications presenting anti-biofilm agents and efflux pump inhibitors from natural sources falls within the scope of this Topic.
-Studies of combination effects and synergism among antimicrobials and natural products are welcomed.
-Computational studies focusing on the anti-infective effects of natural products are within the scope of this research Topic.
-We are interested in nanoformulations of natural extracts, fractions, essential oils, or isolated pure compounds with potential anti-infective activity. If the extracts are to be used, they should be phytochemically characterized.
-Biotechnology and the production of anti-infective agents fall within the scope of this Research Topic.
Nature is a fertile source for providing promising secondary metabolites from plants, animal sources, marine organisms, and endophytes with potential biological activities. Scientists are in continuous search for natural anti-infective molecules to help alleviate simple and life-threatening ailments. The presence of antibiotic resistance by many microbes, their rising frequency and the ability of some microbes to develop biofilms, mandates the search for new antimicrobials which can be guided by evidence-based anti-infective effects reported by natural extracts, oils or their isolated components, which can modulate the antibiotic resistance and make the microbial infection become more liable for treatment. Incorporating natural products in a pharmaceutical form or the use of nanotechnology in formulating a delivery system of these natural anti-infective agents can ease and fasten their delivery to target organs.
Antimicrobial natural products can help overcome the problem of the continuous rise of resistant strains of bacteria, and fungi towards many drugs. In addition, natural compounds are relatively safe compared with their synthetic counterparts. Essential oils, natural extracts, fractions, and isolated pure compounds proved highly effective in tackling food-borne pathogens, urinary tract infection-causing bacteria and other human ailments related to microbial infection. Many potential antimicrobial therapeutics as efflux pump inhibitors and anti-biofilm agents have attracted researchers via unravelling their mechanistic approaches against bacterial pathogens. Nanotechnology has been extensively used to ensure the delivery of molecules to their target organs, minimize the dose, increase the bioavailability of the drug, and present a suitable pharmaceutical drug formulation. Nanotechnology scientists joined forces with natural products chemists to produce highly effective anti-infective agents. Biotechnology entered the race to produce highly effective anti-infective agents by the application of biotechnological principles for the production of anti-infective agents from fungi and bacteria.
Authors are encouraged to submit original research articles or reviews that include but are not limited to any of the following topics:
-Antimicrobial activity of natural products especially those containing polyphenols or terpenes.
-Presenting the molecular mechanism of action is highly recommended. Manuscripts testing the antimicrobial activity by measuring only the zone of inhibition will not be considered.
-Publications presenting anti-biofilm agents and efflux pump inhibitors from natural sources falls within the scope of this Topic.
-Studies of combination effects and synergism among antimicrobials and natural products are welcomed.
-Computational studies focusing on the anti-infective effects of natural products are within the scope of this research Topic.
-We are interested in nanoformulations of natural extracts, fractions, essential oils, or isolated pure compounds with potential anti-infective activity. If the extracts are to be used, they should be phytochemically characterized.
-Biotechnology and the production of anti-infective agents fall within the scope of this Research Topic.
