New Insights Into the Role of Neuroinflammation and Glial Cells in the Development of Neurological Disorders

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Background

Glial cells are non-neuronal cells that constitute a large fraction of the human nervous system. Under physiological conditions, these cells are responsible of maintaining homeostasis by regulating different processes including neurogenesis, synaptogenesis, neuronal excitability and synaptic connectivity. Importantly, they also play a pivotal role in mediating neuroinflammation, which is defined as an inflammation of the nervous tissue and has been identified as a hallmark of several neurological and neurodegenerative disorders such as Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer's disease. Consequently, trying to understand the contribution of neuroinflammation and the role of the different types of glia in the development of these diseases has become one of the main focus of neuroscience research in the last years.



Along the years, neuroinflammation has been pointed out as a key player in various neurological disorders, including neurodegenerative diseases. Neuroinflammation is a complex and dynamic process orchestrated by the cross-talk between several groups of glial cells in the central nervous system (CNS) and peripheral immune cells. However, our understanding of how glial cells interact with each other to shape the distinctive immune responses of the CNS and their contribution to specific neurological disorders remains limited. Here, we aim to publish a collection of articles giving new insights into the role of neuroinflammation in the development of neurological diseases and the contribution of the different glial cells types to this process.



ope of the present collection is to generate a selection of original research articles supporting new evidence about the contribution of neuroinflammation to neurological disorders and the specific roles played by glia in this process. Review articles focused on the recent advances about the involvement of glia and neuroinflammation in neurological diseases could also be considered.



Ideally, the themes to be address would be:



- How neuroinflammation contributes to the development of neurological disorders?

- Which is the role of glia (microglia, astrocytes, olygodendrocytes…) in neurological disorders?

- Is neuroinflammation the cause or the consequence of neurological disorders?

- Targeting neuroinflammation or other processes involving glial cells to treat neurological disorders.

Keywords: Neuroinflammation, glia, neurological disorders, neurodegeneration, disease development

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