As a hereditary, aging-associated neurodegenerative disease, Alzheimer’s disease (AD) has become a global health crisis. In the past few decades, significant efforts have been made to understand AD’s disease mechanism and develop tools for early risk forecasting and diagnosis. Recent genetic studies have identified numerous genetic variants that play a role in AD pathogenesis. Studies on fluid biomarkers have also identified proteins in cerebrospinal fluid and plasma that accurately reflect disease severity.
However, most of these studies were conducted in European-descent populations, with only a few focusing on Asian populations, which represent more than half of the global population. Asian populations likely have alternative disease genetic risk factors because of genetic and lifestyle differences as compared to European-descent populations. TREM2 R47H, for example, is very uncommon in Asian populations, whereas the alternative AD risk TREM2 mutation H157Y, found in Asian populations, is rare in European populations. Meanwhile, currently available biomarkers need to be further evaluated before they can be applied to clinical research in Asian populations.
This Research Topic will aim to raise awareness of Alzheimer’s disease and dementia research in Asian populations, and to provide an opportunity to share research findings and develop potential future collaborations in this research area. It will tackle the status of the research on Alzheimer’s disease in Asian populations and discuss the most recent research findings.
Authors are encouraged to submit research articles and reviews on the following aspects:
• Studies on genetic risk factors and biomarkers for Alzheimer’s disease in Asian populations
• Current clinical practices for Alzheimer’s disease diagnosis and therapy in Asian populations
• Reports on valuable cohorts for Alzheimer’s disease in Asian populations
As a hereditary, aging-associated neurodegenerative disease, Alzheimer’s disease (AD) has become a global health crisis. In the past few decades, significant efforts have been made to understand AD’s disease mechanism and develop tools for early risk forecasting and diagnosis. Recent genetic studies have identified numerous genetic variants that play a role in AD pathogenesis. Studies on fluid biomarkers have also identified proteins in cerebrospinal fluid and plasma that accurately reflect disease severity.
However, most of these studies were conducted in European-descent populations, with only a few focusing on Asian populations, which represent more than half of the global population. Asian populations likely have alternative disease genetic risk factors because of genetic and lifestyle differences as compared to European-descent populations. TREM2 R47H, for example, is very uncommon in Asian populations, whereas the alternative AD risk TREM2 mutation H157Y, found in Asian populations, is rare in European populations. Meanwhile, currently available biomarkers need to be further evaluated before they can be applied to clinical research in Asian populations.
This Research Topic will aim to raise awareness of Alzheimer’s disease and dementia research in Asian populations, and to provide an opportunity to share research findings and develop potential future collaborations in this research area. It will tackle the status of the research on Alzheimer’s disease in Asian populations and discuss the most recent research findings.
Authors are encouraged to submit research articles and reviews on the following aspects:
• Studies on genetic risk factors and biomarkers for Alzheimer’s disease in Asian populations
• Current clinical practices for Alzheimer’s disease diagnosis and therapy in Asian populations
• Reports on valuable cohorts for Alzheimer’s disease in Asian populations