In recent years, inflammation has been found to be involved in the pathogenesis of a wide range of neurological diseases, including cerebrovascular diseases, depression, multiple sclerosis, Alzheimer's disease, Parkinson's disease, especially in cognition- and/or emotion-related diseases. Abnormalities in the neuroinflammatory networks of the central nervous system (CNS) occur before visible structural damage to the brain appears. Cognition and emotion affect each other, and the complex inflammatory responses are one of the important mediating mechanisms.
Brain gray matter has been the focus of research on cognitive or emotional disorders for a long time, but recently numerous previous studies have suggested that brain white matter may play a very important role. In white matter, there are plenty of glial cells, including microglia, astrocytes, and oligodendrocytes, which are important initiating factors or cofactors of inflammation, and the crosstalk among them or their interactions have a significant impact on the clinical manifestations and progression of affective/cognitive disorders. In recent years, advances in functional magnetic resonance (fMRI) have made it possible to visualize inflammatory damage in white matter associated with affective/cognitive impairment, which can be located, qualitatively or quantitatively.
Both basic and clinical studies are looking for inflammatory markers related to emotional and cognitive disorders in imaging or body fluids. Therefore, we aim to gather basic science and clinical research in these areas, which may provide new strategies for the study of cognition- and emotion-related dysfunction.
Research areas covered include but are not limited to:
1. The relationship between cognitive or emotional changes and neuroinflammation
2. Glial cells and neuroinflammation
3. White matter lesions and cognitive and emotional changes
4. Neuroinflammation networks or relevant gene regulation of cognitive or emotional changes
5. Neuroimaging and functional imaging studies of cognition or emotion
6. Effects of anti-inflammatory medication on cognition or mood
7. Inflammatory markers in imaging of the white matter or body fluids associated with emotional and cognitive disorders
In recent years, inflammation has been found to be involved in the pathogenesis of a wide range of neurological diseases, including cerebrovascular diseases, depression, multiple sclerosis, Alzheimer's disease, Parkinson's disease, especially in cognition- and/or emotion-related diseases. Abnormalities in the neuroinflammatory networks of the central nervous system (CNS) occur before visible structural damage to the brain appears. Cognition and emotion affect each other, and the complex inflammatory responses are one of the important mediating mechanisms.
Brain gray matter has been the focus of research on cognitive or emotional disorders for a long time, but recently numerous previous studies have suggested that brain white matter may play a very important role. In white matter, there are plenty of glial cells, including microglia, astrocytes, and oligodendrocytes, which are important initiating factors or cofactors of inflammation, and the crosstalk among them or their interactions have a significant impact on the clinical manifestations and progression of affective/cognitive disorders. In recent years, advances in functional magnetic resonance (fMRI) have made it possible to visualize inflammatory damage in white matter associated with affective/cognitive impairment, which can be located, qualitatively or quantitatively.
Both basic and clinical studies are looking for inflammatory markers related to emotional and cognitive disorders in imaging or body fluids. Therefore, we aim to gather basic science and clinical research in these areas, which may provide new strategies for the study of cognition- and emotion-related dysfunction.
Research areas covered include but are not limited to:
1. The relationship between cognitive or emotional changes and neuroinflammation
2. Glial cells and neuroinflammation
3. White matter lesions and cognitive and emotional changes
4. Neuroinflammation networks or relevant gene regulation of cognitive or emotional changes
5. Neuroimaging and functional imaging studies of cognition or emotion
6. Effects of anti-inflammatory medication on cognition or mood
7. Inflammatory markers in imaging of the white matter or body fluids associated with emotional and cognitive disorders
