The role of neuroendocrine hormones (e.g. melatonin, corticotropin-releasing hormone, gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, brain-derived neurotrophic factor, Oxytocin, growth hormone) in infertility-related diseases (e.g. premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS), endometriosis(EMT), oligospermatism, azoospermatism) has been attracting increasing attention from researchers. These neuroendocrine hormones are present in follicular fluid and ovarian granulosa cells, uterus, placenta, and male reproductive system and may regulate oxidative stress, autophagy, cell cycle, and apoptosis, through mitogen-activated protein kinase (MAPK), PI3k-AKT, mTOR, notch, or wnt signaling pathway or other pathways. Furthermore, they may affect the secretion of hormones (e.g. estrogen, progestogen, androgen) of ovarian granulosa cells and testicular interstitial cells, and ultimately affect the maturation of follicles and sperm, leading to sterility-related diseases.. It is necessary to understand the role of neuroendocrine hormones on infertility-related diseases as well as the underlying mechanisms and clinical applications.
This Research Topic aims to provide an overview of what is known about the neuroendocrine hormones in infertility-related diseases, to discuss recent advancements, and to explore the underlying mechanisms and clinical applications. This Research Topic calls for submissions of Original Research papers, Case Reports, and Review articles regarding the understanding of the mechanism and clinical application of neuroendocrine hormones in infertility-related diseases, as listed but not limited to the following:
• neuroendocrine hormones in POI, PCOS, and EMT
• neuroendocrine hormones in oligospermatism and azoospermatism
• neuroendocrine hormones and oocyte maturation process in vitro
• neuroendocrine hormones and embryonic development
• neuroendocrine hormones and ovarian granulosa cells
• neuroendocrine hormones and testicular interstitial cells
The role of neuroendocrine hormones (e.g. melatonin, corticotropin-releasing hormone, gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, brain-derived neurotrophic factor, Oxytocin, growth hormone) in infertility-related diseases (e.g. premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS), endometriosis(EMT), oligospermatism, azoospermatism) has been attracting increasing attention from researchers. These neuroendocrine hormones are present in follicular fluid and ovarian granulosa cells, uterus, placenta, and male reproductive system and may regulate oxidative stress, autophagy, cell cycle, and apoptosis, through mitogen-activated protein kinase (MAPK), PI3k-AKT, mTOR, notch, or wnt signaling pathway or other pathways. Furthermore, they may affect the secretion of hormones (e.g. estrogen, progestogen, androgen) of ovarian granulosa cells and testicular interstitial cells, and ultimately affect the maturation of follicles and sperm, leading to sterility-related diseases.. It is necessary to understand the role of neuroendocrine hormones on infertility-related diseases as well as the underlying mechanisms and clinical applications.
This Research Topic aims to provide an overview of what is known about the neuroendocrine hormones in infertility-related diseases, to discuss recent advancements, and to explore the underlying mechanisms and clinical applications. This Research Topic calls for submissions of Original Research papers, Case Reports, and Review articles regarding the understanding of the mechanism and clinical application of neuroendocrine hormones in infertility-related diseases, as listed but not limited to the following:
• neuroendocrine hormones in POI, PCOS, and EMT
• neuroendocrine hormones in oligospermatism and azoospermatism
• neuroendocrine hormones and oocyte maturation process in vitro
• neuroendocrine hormones and embryonic development
• neuroendocrine hormones and ovarian granulosa cells
• neuroendocrine hormones and testicular interstitial cells