Sepsis, a life-threatening symptom with disturbed host responses to severe infection, accounts for the majority of death in hospitalized patients. Thanks to the advances in antibiotics and life-supporting techniques, the mortality of septic patients have been decreasing in recent decades. Nevertheless, current intervention is limited in clinics due to the complexity of the causes and the poor understanding of the pathogenic mechanisms. Moreover, the prevalence of sepsis is increasing globally with an augment of multidrug-resistant bacteria, viral infection, and the aging population. Thus, it is urged to develop or update therapeutic medicines or strategies for improving the outcome in the treatment of sepsis.
This Research Topic aims to reveal the regional or global burden, the underlying mechanism, the therapeutic medicine, and the interventional strategy for rescuing sepsis. Based on the scientific evidence provided in the issue, an updated interpretation would be given for the pathogenesis and the treatment of sepsis or sepsis-associated complications, including disseminated intravascular coagulation, acute organ injury, multiple organ dysfunction syndromes, etc.
We welcome original research articles and reviews that cover areas including but not limited to:
• The cause (such as COVID19), the burden, and the current management of sepsis.
• Molecular mechanism regulating the pathogenesis of sepsis.
• Novel strategy for early diagnosis and prevention of sepsis.
• New medicines or techniques for the treatment of sepsis.
• Novel application of existing drugs for the treatment of sepsis.
Sepsis, a life-threatening symptom with disturbed host responses to severe infection, accounts for the majority of death in hospitalized patients. Thanks to the advances in antibiotics and life-supporting techniques, the mortality of septic patients have been decreasing in recent decades. Nevertheless, current intervention is limited in clinics due to the complexity of the causes and the poor understanding of the pathogenic mechanisms. Moreover, the prevalence of sepsis is increasing globally with an augment of multidrug-resistant bacteria, viral infection, and the aging population. Thus, it is urged to develop or update therapeutic medicines or strategies for improving the outcome in the treatment of sepsis.
This Research Topic aims to reveal the regional or global burden, the underlying mechanism, the therapeutic medicine, and the interventional strategy for rescuing sepsis. Based on the scientific evidence provided in the issue, an updated interpretation would be given for the pathogenesis and the treatment of sepsis or sepsis-associated complications, including disseminated intravascular coagulation, acute organ injury, multiple organ dysfunction syndromes, etc.
We welcome original research articles and reviews that cover areas including but not limited to:
• The cause (such as COVID19), the burden, and the current management of sepsis.
• Molecular mechanism regulating the pathogenesis of sepsis.
• Novel strategy for early diagnosis and prevention of sepsis.
• New medicines or techniques for the treatment of sepsis.
• Novel application of existing drugs for the treatment of sepsis.