Atherosclerosis can affect any artery in the body, including arteries in the heart, brain, arms, legs, pelvis, and kidneys. As a result, different diseases (ischemic heart disease, carotid artery disease, peripheral artery disease, ischemic stroke, and chronic kidney disease) may develop based on which arteries are affected.
Atherosclerosis-related diseases are a global crisis and require a global response. The increasing global crisis in atherosclerosis-related diseases is a barrier to development goals including poverty reduction, health equity, economic stability, and human security.
There is a synergic action between genetic, ambient, local, and systemic factors, and ultimately the progression of atherosclerosis is responsible for coronary heart disease (CHD) and its complications (such as unstable “in crescendo” angina, myocardial infarction, and sudden death), peripheral arterial disease, and ischemic stroke. Recent investigations show that mitochondrial alterations, oxidative stress and inflammation are inextricably linked and play major roles in the onset and development of atherosclerosis-related diseases. Long-term oxidative stress, autophagy and vascular inflammation could
lead to atherosclerosis-related diseases. The evidence of oxidative stress, inflammation, autophagy, mitochondrial dynamic dysfunction, and the interaction of those factors had been proposed.
In this Research Topic, we will discuss the role of oxidative stress in atherosclerosis-related diseases, the interaction role of oxidative stress, inflammation, autophagy, mitochondrial dynamic dysfunction in atherosclerosis-related diseases. We will also delineate treatment, rehabilitation and prevention options of oxidative stress for atherosclerosis-related diseases and related risk factors. Finally, a particular mention will be made for the potential benefit of monitoring oxidative stress, inflammation and autophagy in the prevention and treatment of atherosclerosis-related diseases.
We solicit original research articles and comprehensive reviews related to the following themes. Basic sciences and clinical research articles are welcome.
Suggested sub-topics include:
1) Epidemiological characteristics and risk factors of atherosclerosis-related diseases.
2) The physiological and pathogenesis role of oxidative stress in atherosclerosis-related diseases.
3) Main prevention, diagnosis and treatment strategies for oxidative stress in atherosclerosis-related diseases.
4) From basic to clinical application - clinical translational research in oxidative medicine and atherosclerosis-related diseases.
5) Oxidation, inflammation and autophagy, a molecular link between atherosclerosis-related diseases.
6) Oxidative stress and DNA damage in atherosclerosis-related diseases.
7) The potential benefit of monitoring oxidative stress and inflammation in the prevention of atherosclerosis-related diseases.
8) Oxidative stress and inflammation as targets for novel preventive and therapeutic approaches in atherosclerosis-related diseases.
9) The role of redox signalling and oxidative stress pathways in atherosclerosis-related diseases.
10) Reactive oxygen species generation, impacts on tissue oxidation and dietary management of atherosclerosis-related diseases.
Atherosclerosis can affect any artery in the body, including arteries in the heart, brain, arms, legs, pelvis, and kidneys. As a result, different diseases (ischemic heart disease, carotid artery disease, peripheral artery disease, ischemic stroke, and chronic kidney disease) may develop based on which arteries are affected.
Atherosclerosis-related diseases are a global crisis and require a global response. The increasing global crisis in atherosclerosis-related diseases is a barrier to development goals including poverty reduction, health equity, economic stability, and human security.
There is a synergic action between genetic, ambient, local, and systemic factors, and ultimately the progression of atherosclerosis is responsible for coronary heart disease (CHD) and its complications (such as unstable “in crescendo” angina, myocardial infarction, and sudden death), peripheral arterial disease, and ischemic stroke. Recent investigations show that mitochondrial alterations, oxidative stress and inflammation are inextricably linked and play major roles in the onset and development of atherosclerosis-related diseases. Long-term oxidative stress, autophagy and vascular inflammation could
lead to atherosclerosis-related diseases. The evidence of oxidative stress, inflammation, autophagy, mitochondrial dynamic dysfunction, and the interaction of those factors had been proposed.
In this Research Topic, we will discuss the role of oxidative stress in atherosclerosis-related diseases, the interaction role of oxidative stress, inflammation, autophagy, mitochondrial dynamic dysfunction in atherosclerosis-related diseases. We will also delineate treatment, rehabilitation and prevention options of oxidative stress for atherosclerosis-related diseases and related risk factors. Finally, a particular mention will be made for the potential benefit of monitoring oxidative stress, inflammation and autophagy in the prevention and treatment of atherosclerosis-related diseases.
We solicit original research articles and comprehensive reviews related to the following themes. Basic sciences and clinical research articles are welcome.
Suggested sub-topics include:
1) Epidemiological characteristics and risk factors of atherosclerosis-related diseases.
2) The physiological and pathogenesis role of oxidative stress in atherosclerosis-related diseases.
3) Main prevention, diagnosis and treatment strategies for oxidative stress in atherosclerosis-related diseases.
4) From basic to clinical application - clinical translational research in oxidative medicine and atherosclerosis-related diseases.
5) Oxidation, inflammation and autophagy, a molecular link between atherosclerosis-related diseases.
6) Oxidative stress and DNA damage in atherosclerosis-related diseases.
7) The potential benefit of monitoring oxidative stress and inflammation in the prevention of atherosclerosis-related diseases.
8) Oxidative stress and inflammation as targets for novel preventive and therapeutic approaches in atherosclerosis-related diseases.
9) The role of redox signalling and oxidative stress pathways in atherosclerosis-related diseases.
10) Reactive oxygen species generation, impacts on tissue oxidation and dietary management of atherosclerosis-related diseases.