Transient receptor potential (TRP) represents a super family of ion channels expressed in all animal kingdom, where they take part in many cellular functions. The family is sub-divided into seven major subfamilies: TRPC (canonical), TRPV (vanilloid), TRPA (ankyrin) TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPN (also known as NOMPC (no mechanoreceptor potential C). TRP proteins are mostly unselective channels for monovalent and divalent cations and are gated by numerous stimuli such as temperature, chemical substances, mechanical and osmotic stress or signaling molecules. In the last decade an increasing number of studies indicate TRP channels are biomarkers of cardiac disorders, diabetes, digestive disorders, or cancer. As such, the TRPM family was proved to participate in the migration and proliferation of cancer cells, the TRPV2 is expressed and is involved in the function of macrophages, whereas TRPA1 modulates the oxidative stress in melanoma, breast cancer or endothelial cells.
In this Research Topic, we aim to examine the mechanisms through which these proteins participate in signaling processes in non-excitable cells, and how their expression, conductive and non-conductive states are related towards physiological and pathophysiological functions such as inflammation, oxidative stress, or tumorigenesis. The unmet need of using ion channels as biomarkers or targets in different diseases is limited by contradictory results obtained from different groups, which denote that gene expression pattern and biophysical features are strongly modulated by cell environment and different signaling pathways. Therefore, the general objective of this Research Topic is to stimulate multidisciplinary research that brings together scientists with expertise in biophysics, cellular or molecular biology who may present: i) new research in the field, ii) reviews or systematic reviews that bring new perspectives of important literature to date, or III) new methods to investigate these membrane proteins with putative roles as biomarkers for various diseases.
Within this Research Topic we would like to address research exploring:
• Expression, function and signaling pathways of TRP channels in tumorigenesis processes
• Endogenous modulators of TRP functions in non-excitable tissues
• Role, function and signaling pathways of TRP channels in inflammatory processes
• New perspective that relates the conductive and nonconductive states with cellular functions
• New methods to investigate TRP channels and signaling pathways in non-excitable cells
• Modelling studies addressing structure-function relationships
• Studies on TRP trafficking and expression
• Roles of TRP channels as biomarkers or therapy targets in various diseases
We welcome submissions of Original Research, Brief Research Reports, Review and Mini Reviews, Systematic Reviews and Methods
Transient receptor potential (TRP) represents a super family of ion channels expressed in all animal kingdom, where they take part in many cellular functions. The family is sub-divided into seven major subfamilies: TRPC (canonical), TRPV (vanilloid), TRPA (ankyrin) TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPN (also known as NOMPC (no mechanoreceptor potential C). TRP proteins are mostly unselective channels for monovalent and divalent cations and are gated by numerous stimuli such as temperature, chemical substances, mechanical and osmotic stress or signaling molecules. In the last decade an increasing number of studies indicate TRP channels are biomarkers of cardiac disorders, diabetes, digestive disorders, or cancer. As such, the TRPM family was proved to participate in the migration and proliferation of cancer cells, the TRPV2 is expressed and is involved in the function of macrophages, whereas TRPA1 modulates the oxidative stress in melanoma, breast cancer or endothelial cells.
In this Research Topic, we aim to examine the mechanisms through which these proteins participate in signaling processes in non-excitable cells, and how their expression, conductive and non-conductive states are related towards physiological and pathophysiological functions such as inflammation, oxidative stress, or tumorigenesis. The unmet need of using ion channels as biomarkers or targets in different diseases is limited by contradictory results obtained from different groups, which denote that gene expression pattern and biophysical features are strongly modulated by cell environment and different signaling pathways. Therefore, the general objective of this Research Topic is to stimulate multidisciplinary research that brings together scientists with expertise in biophysics, cellular or molecular biology who may present: i) new research in the field, ii) reviews or systematic reviews that bring new perspectives of important literature to date, or III) new methods to investigate these membrane proteins with putative roles as biomarkers for various diseases.
Within this Research Topic we would like to address research exploring:
• Expression, function and signaling pathways of TRP channels in tumorigenesis processes
• Endogenous modulators of TRP functions in non-excitable tissues
• Role, function and signaling pathways of TRP channels in inflammatory processes
• New perspective that relates the conductive and nonconductive states with cellular functions
• New methods to investigate TRP channels and signaling pathways in non-excitable cells
• Modelling studies addressing structure-function relationships
• Studies on TRP trafficking and expression
• Roles of TRP channels as biomarkers or therapy targets in various diseases
We welcome submissions of Original Research, Brief Research Reports, Review and Mini Reviews, Systematic Reviews and Methods
