Whole-body homeostasis is maintained by a complex network of inter-organ cross-talk and organ intra-cellular communication. Fluctuation in the energy balance is received by a given cell type and shared with other cell types in various organs to inform diverse cellular decisions including expansion, differentiation, or activation of programmed cell death. Growing events indicate that chronic overnutrition promoting disruption of those interactions leads to pathological conditions such as type 2 diabetes, liver diseases, cardiovascular diseases, and cancer. In recent decades the technological advances in both omics high throughput approaches and the development in multicellular in vitro culture systems have provided new opportunities to understand systemic metabolic cross-talk and its underlying mechanisms.
Here we aim to collect original research that uses experimental models or clinical studies to identify cellular cross-talks during fluctuation of energy balance using innovative approaches. These include, but are not limited to:
• Organ cross-talk in metabolic diseases;
• Paracrine and endocrine communication within one organ;
• Perturbation in organ cross-talks promoting other diseases such as cancer and cardiovascular diseases;
• Co-culture and organoids models for cellular communication;
• Clinical studies linking metabolic disruption to other diseases;
• Technological advances to study organ cross-talk and cellular communication.
The goal of this topic is to generate a collection of original research articles, reviews, and perspectives that capitalize on the recent technological advances to elucidate how metabolic status influence inter-organ crosstalk and cell-cell communication.
Whole-body homeostasis is maintained by a complex network of inter-organ cross-talk and organ intra-cellular communication. Fluctuation in the energy balance is received by a given cell type and shared with other cell types in various organs to inform diverse cellular decisions including expansion, differentiation, or activation of programmed cell death. Growing events indicate that chronic overnutrition promoting disruption of those interactions leads to pathological conditions such as type 2 diabetes, liver diseases, cardiovascular diseases, and cancer. In recent decades the technological advances in both omics high throughput approaches and the development in multicellular in vitro culture systems have provided new opportunities to understand systemic metabolic cross-talk and its underlying mechanisms.
Here we aim to collect original research that uses experimental models or clinical studies to identify cellular cross-talks during fluctuation of energy balance using innovative approaches. These include, but are not limited to:
• Organ cross-talk in metabolic diseases;
• Paracrine and endocrine communication within one organ;
• Perturbation in organ cross-talks promoting other diseases such as cancer and cardiovascular diseases;
• Co-culture and organoids models for cellular communication;
• Clinical studies linking metabolic disruption to other diseases;
• Technological advances to study organ cross-talk and cellular communication.
The goal of this topic is to generate a collection of original research articles, reviews, and perspectives that capitalize on the recent technological advances to elucidate how metabolic status influence inter-organ crosstalk and cell-cell communication.
