The skin is a fundamental element of the continuous outside-in and inside-out cross-talk with the internal and external environment and is constantly solicited to develop an appropriate response to a plethora of different stimuli. Due to its peculiar cellular composition, the epidermis not only represents a physical and chemical barrier but also an immunological shield against potential incoming pathogens, thus encompassing a wide range of potential responses. However, recent evidence has begun to highlight the importance of the skin in the innate and adaptive immune system, not only in host defense but also as a driver of cutaneous diseases. Moreover, it is now well known that also non-hematopoietic cells, such as keratinocytes, actively participate in all the immunological processes occurring at the skin barrier.
Thanks to availability of several in vivo and in vitro models very closely reproducing the biological conditions observed in patients, interest in the immunobiology of the skin has been progressively increasing over the decade. Interest had not only peaked among dermatologists but also among basic and translational scientists. The goal of this special issue is to collect high-quality scientific studies describing and dissecting the main cellular and molecular mechanisms triggered by a wide range of immune and non-immune stimuli able to preserve skin function or to alter skin homeostasis, paving the way for the development of novel therapeutic interventions for better management or prevention of skin diseases.
We welcome submissions of Original research, Review article, Mini-Reviews and Opinion articles, with a goal of investigating and better understanding the main different external stimuli triggering a cytokine- or immuno-mediated skin response, and how that ultimately lead to skin pathogenesis. We welcome submissions based on (but not limited to):
• The relationship between immuno-mediated skin diseases and (micro)environment
• The relationship between radiations (UVA, UVB, gamma rays) and immuno-mediated skin response
• The relationship between diet and immuno-mediated skin response
• Relationship between skin microbiota and TLRs in health and disease
• Skin diseases associated with TLR mutations
• Skin modelling
• Effects of immunomodulatory agents on epidermal barrier structure and function
• The relationship between immune modulation and microenvironment modifications
The skin is a fundamental element of the continuous outside-in and inside-out cross-talk with the internal and external environment and is constantly solicited to develop an appropriate response to a plethora of different stimuli. Due to its peculiar cellular composition, the epidermis not only represents a physical and chemical barrier but also an immunological shield against potential incoming pathogens, thus encompassing a wide range of potential responses. However, recent evidence has begun to highlight the importance of the skin in the innate and adaptive immune system, not only in host defense but also as a driver of cutaneous diseases. Moreover, it is now well known that also non-hematopoietic cells, such as keratinocytes, actively participate in all the immunological processes occurring at the skin barrier.
Thanks to availability of several in vivo and in vitro models very closely reproducing the biological conditions observed in patients, interest in the immunobiology of the skin has been progressively increasing over the decade. Interest had not only peaked among dermatologists but also among basic and translational scientists. The goal of this special issue is to collect high-quality scientific studies describing and dissecting the main cellular and molecular mechanisms triggered by a wide range of immune and non-immune stimuli able to preserve skin function or to alter skin homeostasis, paving the way for the development of novel therapeutic interventions for better management or prevention of skin diseases.
We welcome submissions of Original research, Review article, Mini-Reviews and Opinion articles, with a goal of investigating and better understanding the main different external stimuli triggering a cytokine- or immuno-mediated skin response, and how that ultimately lead to skin pathogenesis. We welcome submissions based on (but not limited to):
• The relationship between immuno-mediated skin diseases and (micro)environment
• The relationship between radiations (UVA, UVB, gamma rays) and immuno-mediated skin response
• The relationship between diet and immuno-mediated skin response
• Relationship between skin microbiota and TLRs in health and disease
• Skin diseases associated with TLR mutations
• Skin modelling
• Effects of immunomodulatory agents on epidermal barrier structure and function
• The relationship between immune modulation and microenvironment modifications