The morbidity and mortality of cardiovascular diseases caused by diabetes are evident worldwide. Recently, much attention has been drawn to the occurrence of cardiomyopathy and heart failure caused by diabetes. Diabetic cardiomyopathy and heart failure have been shown to be related to hyperglycemia, insulin resistance, and others. The chronic metabolic imbalance may develop into diabetes and therefore leads to the progression of cardiac dysfunction and even heart failure. Yet the detailed mechanisms still need to be uncovered. There are multiple successful animal models generated based on either the feeding manipulation or specific molecular pathways involved in cardiac morphogenesis and cardiac function in diabetes. Unfortunately, these models cannot be directly translated into clinical applications, thus, the mechanisms in human patients remain poorly understood. Hence, it requires further understanding of genetic and molecular regulation of the disease progression, including mitochondrial dysfunction, ER stress, inflammation, autophagy, and others.
This Research Topic aims to collect the latest findings and results of molecular mechanisms and genetic studies, in order to deepen and widen the understandings of the mechanisms of diabetes-caused heart failure. We hope to explore whether specific genotypes or alleles are associated with diabetes-induced heart failure.
Within this Research Topic, we aim to uncover genetic and molecular mechanisms in individuals with diabetes-caused heart failure. We welcome original research, review, and methodological articles studying the state-of-the-art and future perspectives in basic and translational research about heart failure caused by diabetes. Areas of interest include but are not limited to:
• Next-generation sequencing, linkage analysis, and genome-wide association study (GWAS) for cardiac dysfunction caused by diabetes
• The mechanisms of newly reported aberrations of genetics and genomics in diabetes-induced heart failure
• Molecular and cellular mechanisms involved in the process of heart failure in diabetic conditions
• The effects of metabolic disorder on cardiac function under diabetic conditions
• Therapeutics strategies for diabetes-induced heart failure
The morbidity and mortality of cardiovascular diseases caused by diabetes are evident worldwide. Recently, much attention has been drawn to the occurrence of cardiomyopathy and heart failure caused by diabetes. Diabetic cardiomyopathy and heart failure have been shown to be related to hyperglycemia, insulin resistance, and others. The chronic metabolic imbalance may develop into diabetes and therefore leads to the progression of cardiac dysfunction and even heart failure. Yet the detailed mechanisms still need to be uncovered. There are multiple successful animal models generated based on either the feeding manipulation or specific molecular pathways involved in cardiac morphogenesis and cardiac function in diabetes. Unfortunately, these models cannot be directly translated into clinical applications, thus, the mechanisms in human patients remain poorly understood. Hence, it requires further understanding of genetic and molecular regulation of the disease progression, including mitochondrial dysfunction, ER stress, inflammation, autophagy, and others.
This Research Topic aims to collect the latest findings and results of molecular mechanisms and genetic studies, in order to deepen and widen the understandings of the mechanisms of diabetes-caused heart failure. We hope to explore whether specific genotypes or alleles are associated with diabetes-induced heart failure.
Within this Research Topic, we aim to uncover genetic and molecular mechanisms in individuals with diabetes-caused heart failure. We welcome original research, review, and methodological articles studying the state-of-the-art and future perspectives in basic and translational research about heart failure caused by diabetes. Areas of interest include but are not limited to:
• Next-generation sequencing, linkage analysis, and genome-wide association study (GWAS) for cardiac dysfunction caused by diabetes
• The mechanisms of newly reported aberrations of genetics and genomics in diabetes-induced heart failure
• Molecular and cellular mechanisms involved in the process of heart failure in diabetic conditions
• The effects of metabolic disorder on cardiac function under diabetic conditions
• Therapeutics strategies for diabetes-induced heart failure