The use of animal models is critical for elucidating diseases pathological mechanisms. Some diseases in humans are similar to those that occur in many domestic/company species such as dogs, cats, horses and others. For example, some types of cancer, such as ocular squamous cell carcinoma, mammary tumors and melanomas, not only affect humans but also dogs, cats, horses and other species, as these share much of our biology, environment, and exposure to contaminants, and also respond similarly from the physiological, pathological, and therapeutic perspectives. On the other hand, dogs and cats develop some of the components of the human metabolic syndrome, namely: obesity, insulin resistance, increased blood pressure, and hyperlipidemia; thus, these and other pathologies such as inflammatory bowel disease, mitral valve disease, epilepsy, chronic kidney disease allow these “natural animal models of the disease” to function as a very interesting and promising tool, both from a biological and ethical point of view avoiding the use of models of induction, to diagnose, treat, and prevent diseases of these species, but also serving as models of the same condition in humans with obvious benefits and consolidating the One Health approach beyond transmissible and environmental diseases.
Some diseases in humans are similar to those that occur spontaneously in many domestic/company species such as dogs, cats, horses and others. The purpose of this special issue is to show how these “natural animal models of disease” may constitute very interesting learning opportunities for the same pathologies in humans from a biological and ethical point of view, highlighting the understanding of the pathophysiological mechanism and their importance to prevent the progression of the diseases and the search for new therapeutic strategies and approaches.
This special issue welcomes original research papers, review articles and systematic reviews related to “natural animal models of disease”, including but not limited, to the following topics:
- Factors affecting the reproducibility and translatability of these animal models
- Validation of these alternative models
- Ethical, logistical and welfare considerations and practical aspects related to the use of these models
- Comparative pathology of induced and rodent models
- Short and long-term data on therapeutic, pharmacokinetics and adverse effects of novel drugs
- Comparative studies between these animal models, and comparative human’s diseases with animals
- Refinement of techniques, determining appropriate animal numbers. interpretation of data and the regulation of the use of these models
- New avenue of therapeutic systems
- Advantages and limitations of these natural models
- Animal models of infectious and parasitic diseases
The use of animal models is critical for elucidating diseases pathological mechanisms. Some diseases in humans are similar to those that occur in many domestic/company species such as dogs, cats, horses and others. For example, some types of cancer, such as ocular squamous cell carcinoma, mammary tumors and melanomas, not only affect humans but also dogs, cats, horses and other species, as these share much of our biology, environment, and exposure to contaminants, and also respond similarly from the physiological, pathological, and therapeutic perspectives. On the other hand, dogs and cats develop some of the components of the human metabolic syndrome, namely: obesity, insulin resistance, increased blood pressure, and hyperlipidemia; thus, these and other pathologies such as inflammatory bowel disease, mitral valve disease, epilepsy, chronic kidney disease allow these “natural animal models of the disease” to function as a very interesting and promising tool, both from a biological and ethical point of view avoiding the use of models of induction, to diagnose, treat, and prevent diseases of these species, but also serving as models of the same condition in humans with obvious benefits and consolidating the One Health approach beyond transmissible and environmental diseases.
Some diseases in humans are similar to those that occur spontaneously in many domestic/company species such as dogs, cats, horses and others. The purpose of this special issue is to show how these “natural animal models of disease” may constitute very interesting learning opportunities for the same pathologies in humans from a biological and ethical point of view, highlighting the understanding of the pathophysiological mechanism and their importance to prevent the progression of the diseases and the search for new therapeutic strategies and approaches.
This special issue welcomes original research papers, review articles and systematic reviews related to “natural animal models of disease”, including but not limited, to the following topics:
- Factors affecting the reproducibility and translatability of these animal models
- Validation of these alternative models
- Ethical, logistical and welfare considerations and practical aspects related to the use of these models
- Comparative pathology of induced and rodent models
- Short and long-term data on therapeutic, pharmacokinetics and adverse effects of novel drugs
- Comparative studies between these animal models, and comparative human’s diseases with animals
- Refinement of techniques, determining appropriate animal numbers. interpretation of data and the regulation of the use of these models
- New avenue of therapeutic systems
- Advantages and limitations of these natural models
- Animal models of infectious and parasitic diseases