Tissue engineering is a rapidly advancing interdisciplinary field that involves multiple principles of life sciences, medicine, material sciences, and engineering, which aims to facilitate damaged or missing tissue/organ healing, regeneration, and reconstruction. A range of synthetic and natural materials have been adopted as basic substances to prepare tissue engineering grafts (TEGs). It is worth noting that tissue repair is a complicated biological process, which involves a large variety of molecular mechanisms. Therefore, the exploration for TEGs with therapeutic effects that can make full use of the body’s innate regenerative capabilities has always been an important research direction in tissue engineering.
During the past few decades, to further develop therapeutic TEGs, numerous bioactive cues, such as pharmacological agents, small molecules, cytokines, growth factors, extracellular vesicles, genes, and cells, have been integrated into TEGs. Moreover, varieties of light, electrical, thermal, magnetic, and other stimuli-responsive components have been added to improve the functional properties of TEGs. The incorporation of topological cues to mimic natural tissue microstructure also plays a positive role in tissue repair. Despite progress in regenerative medicine, few technologies have been translated into the clinic. Therapeutic TEGs for various tissue injuries still need to be further optimized to provide more possibilities for achieving ideal functional recovery. Nowadays tissue regeneration after injury remains a great challenge worldwide.
More recently, therapeutic TEGs are under extensive investigation and become a highly promising field. The main goal of this Research Topic is to collect high-quality basic and applied research on the therapeutic TEGs with various biological, chemical, and physical cues to support the restoration of different tissues, such as skin, bone, cartilage, nerve, blood vessel, and cardiac tissue, etc. This Research Topic will focus on the design, preparation, and characterization of innovative therapeutic TEGs as well as their potential application in regenerative medicine. Original Research Articles, Reviews, and Mini Reviews are all welcome contributions to this Research Topic. We welcome submissions covering, but not limited to, the following themes:
• Advances in the development of therapeutic TEGs for tissue repair after injury
• Design, preparation, and characterization of innovative therapeutic TEGs
• Novel fabrication techniques for therapeutic TEGs, including 3D bioprinting, 4D bioprinting, rapid prototyping, and microfluidic-based printing
• Nanotechnology and nanomaterials in developing therapeutic TEGs
• New application of bioactive agents to optimize therapeutic TEGs
• The development of therapeutic TEGs with bioresponsive function
• Microstructure design (such as pore size, shape, arrangement, and surface texture) of therapeutic TEGs
• Underlying molecular mechanisms on cell-biomaterial interaction of therapeutic TEGs
• Translational research and clinical application of therapeutic TEGs
Tissue engineering is a rapidly advancing interdisciplinary field that involves multiple principles of life sciences, medicine, material sciences, and engineering, which aims to facilitate damaged or missing tissue/organ healing, regeneration, and reconstruction. A range of synthetic and natural materials have been adopted as basic substances to prepare tissue engineering grafts (TEGs). It is worth noting that tissue repair is a complicated biological process, which involves a large variety of molecular mechanisms. Therefore, the exploration for TEGs with therapeutic effects that can make full use of the body’s innate regenerative capabilities has always been an important research direction in tissue engineering.
During the past few decades, to further develop therapeutic TEGs, numerous bioactive cues, such as pharmacological agents, small molecules, cytokines, growth factors, extracellular vesicles, genes, and cells, have been integrated into TEGs. Moreover, varieties of light, electrical, thermal, magnetic, and other stimuli-responsive components have been added to improve the functional properties of TEGs. The incorporation of topological cues to mimic natural tissue microstructure also plays a positive role in tissue repair. Despite progress in regenerative medicine, few technologies have been translated into the clinic. Therapeutic TEGs for various tissue injuries still need to be further optimized to provide more possibilities for achieving ideal functional recovery. Nowadays tissue regeneration after injury remains a great challenge worldwide.
More recently, therapeutic TEGs are under extensive investigation and become a highly promising field. The main goal of this Research Topic is to collect high-quality basic and applied research on the therapeutic TEGs with various biological, chemical, and physical cues to support the restoration of different tissues, such as skin, bone, cartilage, nerve, blood vessel, and cardiac tissue, etc. This Research Topic will focus on the design, preparation, and characterization of innovative therapeutic TEGs as well as their potential application in regenerative medicine. Original Research Articles, Reviews, and Mini Reviews are all welcome contributions to this Research Topic. We welcome submissions covering, but not limited to, the following themes:
• Advances in the development of therapeutic TEGs for tissue repair after injury
• Design, preparation, and characterization of innovative therapeutic TEGs
• Novel fabrication techniques for therapeutic TEGs, including 3D bioprinting, 4D bioprinting, rapid prototyping, and microfluidic-based printing
• Nanotechnology and nanomaterials in developing therapeutic TEGs
• New application of bioactive agents to optimize therapeutic TEGs
• The development of therapeutic TEGs with bioresponsive function
• Microstructure design (such as pore size, shape, arrangement, and surface texture) of therapeutic TEGs
• Underlying molecular mechanisms on cell-biomaterial interaction of therapeutic TEGs
• Translational research and clinical application of therapeutic TEGs