There is growing interest in nutrients such as vitamins, minerals, fats and amino acids as signaling modulators in the control of psychological and pathological processes. Altered nutrient metabolism and the related signaling pathways contribute to tumorigenesis and thus serve as a target for cancer therapy. Importantly, due to the favorable safety profile, nutrients hold promise as adjunctive approaches in cancer prevention. An excellent example is the role of retinoids, the group of vitamin A derivatives, in the treatment of hepatocellular carcinoma (HCC). Low serum retinol level had been described as a risk factor for the development of HCC in humans and dominant-negative mutations or phosphorylation-induced inactivation in retinoid receptors promoted HCC development in transgenic mice. Reactivation of retinoid singling with an acyclic retinoid, peretinoin, showed promising therapeutic results in clinical trials to prevent the recurrence of HCC after curative treatment.
The clinical application of nutrients is still challenging due to the ambiguous evidence of effectiveness and lack of predictive biomarkers to identify a high-response subgroup. The individual response to nutrients is highly heterogeneous and is regulated through dynamic signaling networks. Currently, the advent of single-cell transcriptome sequencing and machine learning technologies offered excellent modalities to understand the molecular mechanism of nutrient response in cancer therapy. The aim of this Research Topic is to establish the evidence collection of nutrients in cancer epidemiology and clinical practice and the current views of the chemical and biological basis of natural and synthetic nutrients in cancer biology such as tumor immunology and microenvironment. Furthermore, this Research Topic is aimed to make a significant contribution to the literature to clarify the efficacy of nutrients and to inform further efforts in promoting clinical research into nutrients in cancer prevention and therapy from the perspective of biomarker-based precision medicine.
We encourage submissions of Original Research, Review articles and Perspective articles focusing but not limited to the following terms:
1. Epidemiological evidence of nutrients in cancer risk and prognosis
2. Clinical practices of nutrients in cancer prevention and therapy
3. Chemical advances in natural and synthetic nutrients
4. Molecular signaling and functions of nutrients in cancer biology
5. System biology and machine learning for precision medicine with nutrients
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
There is growing interest in nutrients such as vitamins, minerals, fats and amino acids as signaling modulators in the control of psychological and pathological processes. Altered nutrient metabolism and the related signaling pathways contribute to tumorigenesis and thus serve as a target for cancer therapy. Importantly, due to the favorable safety profile, nutrients hold promise as adjunctive approaches in cancer prevention. An excellent example is the role of retinoids, the group of vitamin A derivatives, in the treatment of hepatocellular carcinoma (HCC). Low serum retinol level had been described as a risk factor for the development of HCC in humans and dominant-negative mutations or phosphorylation-induced inactivation in retinoid receptors promoted HCC development in transgenic mice. Reactivation of retinoid singling with an acyclic retinoid, peretinoin, showed promising therapeutic results in clinical trials to prevent the recurrence of HCC after curative treatment.
The clinical application of nutrients is still challenging due to the ambiguous evidence of effectiveness and lack of predictive biomarkers to identify a high-response subgroup. The individual response to nutrients is highly heterogeneous and is regulated through dynamic signaling networks. Currently, the advent of single-cell transcriptome sequencing and machine learning technologies offered excellent modalities to understand the molecular mechanism of nutrient response in cancer therapy. The aim of this Research Topic is to establish the evidence collection of nutrients in cancer epidemiology and clinical practice and the current views of the chemical and biological basis of natural and synthetic nutrients in cancer biology such as tumor immunology and microenvironment. Furthermore, this Research Topic is aimed to make a significant contribution to the literature to clarify the efficacy of nutrients and to inform further efforts in promoting clinical research into nutrients in cancer prevention and therapy from the perspective of biomarker-based precision medicine.
We encourage submissions of Original Research, Review articles and Perspective articles focusing but not limited to the following terms:
1. Epidemiological evidence of nutrients in cancer risk and prognosis
2. Clinical practices of nutrients in cancer prevention and therapy
3. Chemical advances in natural and synthetic nutrients
4. Molecular signaling and functions of nutrients in cancer biology
5. System biology and machine learning for precision medicine with nutrients
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.