Chronic Respiratory Diseases (CRDs) are represented by chronic airway diseases (CADs), chronic cough, pulmonary fibrosis, pulmonary infection and lung cancer, etc. with the following characteristics: high incidence rate, high disability rate, high mortality. The key risk factors of CRDs include tobacco smoking, environmental pollution, allergen, respiratory infection, population aging, and genetic susceptibility, etc. The prevalence of CRDs is increasing year by year and CRDs have become an important public health problem all over the world.
Although progress has been made on revealing the mechanisms of CRDs and multiple treatments have played beneficial roles in clinical practice, their long-term effect is limited, especially to CRDs comorbidities and overlap syndrome in the real world. Epidemiologists and respiratory physicians found CADs to coexist in some patients with pulmonary infection, lung cancer, etc. Recent studies showed COPD and asthma are closely related to lung cancer on comorbidity and common mechanisms. Based on this phenomenon, researchers explored potentially common mechanistic molecules and signaling pathways between CADs and lung cancer.
This Research Topic aims to collect and highlight the recent advances or key research results in the field of chronic respiratory diseases (CRDs), mainly in chronic airway diseases (CADs) and lung cancer. There are some common genes, molecules or proteins played similar roles in COPD and lung cancer development. For example, epithelial-mesenchymal transition (EMT) was demonstrated to play roles on phenotype mechanisms in both COPD and lung cancer. Here, we welcome high-quality submissions of Original Research, Review, and Clinical Trials on the interaction between CADs and lung cancer and their comorbidity from the perspectives of epidemiology, etiology, pathology, genomics, pathogenesis, treatment, prevention, and management. Topics of interest include the following:
• The relationship between chronic airway diseases and bronchial lung cancer in terms of epidemiology, etiology, pathology, diagnosis, treatment, prevention, and management;
• Multi-omics analysis and statistical modeling on the comorbidities of chronic airway diseases and bronchial lung cancer;
• Exploration of the signaling pathways, key DNAs, RNAs, proteins, and small molecule compounds in the development of chronic airway diseases and bronchial lung cancer.
• Drug discovery, development, and application in co-therapeutic mechanisms.
Chronic Respiratory Diseases (CRDs) are represented by chronic airway diseases (CADs), chronic cough, pulmonary fibrosis, pulmonary infection and lung cancer, etc. with the following characteristics: high incidence rate, high disability rate, high mortality. The key risk factors of CRDs include tobacco smoking, environmental pollution, allergen, respiratory infection, population aging, and genetic susceptibility, etc. The prevalence of CRDs is increasing year by year and CRDs have become an important public health problem all over the world.
Although progress has been made on revealing the mechanisms of CRDs and multiple treatments have played beneficial roles in clinical practice, their long-term effect is limited, especially to CRDs comorbidities and overlap syndrome in the real world. Epidemiologists and respiratory physicians found CADs to coexist in some patients with pulmonary infection, lung cancer, etc. Recent studies showed COPD and asthma are closely related to lung cancer on comorbidity and common mechanisms. Based on this phenomenon, researchers explored potentially common mechanistic molecules and signaling pathways between CADs and lung cancer.
This Research Topic aims to collect and highlight the recent advances or key research results in the field of chronic respiratory diseases (CRDs), mainly in chronic airway diseases (CADs) and lung cancer. There are some common genes, molecules or proteins played similar roles in COPD and lung cancer development. For example, epithelial-mesenchymal transition (EMT) was demonstrated to play roles on phenotype mechanisms in both COPD and lung cancer. Here, we welcome high-quality submissions of Original Research, Review, and Clinical Trials on the interaction between CADs and lung cancer and their comorbidity from the perspectives of epidemiology, etiology, pathology, genomics, pathogenesis, treatment, prevention, and management. Topics of interest include the following:
• The relationship between chronic airway diseases and bronchial lung cancer in terms of epidemiology, etiology, pathology, diagnosis, treatment, prevention, and management;
• Multi-omics analysis and statistical modeling on the comorbidities of chronic airway diseases and bronchial lung cancer;
• Exploration of the signaling pathways, key DNAs, RNAs, proteins, and small molecule compounds in the development of chronic airway diseases and bronchial lung cancer.
• Drug discovery, development, and application in co-therapeutic mechanisms.