As the first line of defense against the invasion of foreign pathogens, leukocytes are often present at the peripheral barrier tissues, including the skin, gastrointestinal and respiratory tracts. In response to infectious challenges, innate immune cells respond quickly, often overcoming the invaders. However, in case the pathogens persist, innate cells alert the adaptive immune cells, which are most abundant in secondary lymphoid organs (SLOs) such as spleen, lymph nodes and Peyer’s patches. Beyond these organs, native immune cells may also reside directly, albeit in rare numbers, in the diseased organ such as tissues that produce tumor, or vascular walls where local inflammation occurs. Due to the limited number and difficulty in purification from these none-lymphoid organs of immune cells, the immunological features of these diseased regions, which might shed interesting light on the direct pathogenesis in the affected organs, are far from clear, hindering the early diagnosis and treatment of the diseases.
The goal of this Research Topic is to provide a forum to advance research on the contribution of regional immunity to the genesis and development of local diseases such as inflammation, autoimmune responses, and tumorigeneses, as well as to explore innovative pharmacological interventions in the attempt to achieve a beneficial impact on the above-mentioned chronic diseases.
We welcome the submissions of Original Research and Review on the sub-topics below:
• Antigen presenting cells in regional immunity
• New development in T cell biology
• T cell immunity in tumor region
• Local immunity of T cell subsets in diseases
• Humoral immunity in local inflammation
As the first line of defense against the invasion of foreign pathogens, leukocytes are often present at the peripheral barrier tissues, including the skin, gastrointestinal and respiratory tracts. In response to infectious challenges, innate immune cells respond quickly, often overcoming the invaders. However, in case the pathogens persist, innate cells alert the adaptive immune cells, which are most abundant in secondary lymphoid organs (SLOs) such as spleen, lymph nodes and Peyer’s patches. Beyond these organs, native immune cells may also reside directly, albeit in rare numbers, in the diseased organ such as tissues that produce tumor, or vascular walls where local inflammation occurs. Due to the limited number and difficulty in purification from these none-lymphoid organs of immune cells, the immunological features of these diseased regions, which might shed interesting light on the direct pathogenesis in the affected organs, are far from clear, hindering the early diagnosis and treatment of the diseases.
The goal of this Research Topic is to provide a forum to advance research on the contribution of regional immunity to the genesis and development of local diseases such as inflammation, autoimmune responses, and tumorigeneses, as well as to explore innovative pharmacological interventions in the attempt to achieve a beneficial impact on the above-mentioned chronic diseases.
We welcome the submissions of Original Research and Review on the sub-topics below:
• Antigen presenting cells in regional immunity
• New development in T cell biology
• T cell immunity in tumor region
• Local immunity of T cell subsets in diseases
• Humoral immunity in local inflammation