Microbial infections lead to long-term chronic inflammation, repeated DNA damage and repair, metabolic homeostasis disorder and immune system unbalance, which communally contribute to the occurrence of gastrointestinal cancers. It has been well recognized that Helicobacter pylori infection can cause systemic diseases and even cancers, such as gastric cancer, colorectal cancer, and cholangiocarcinoma. Other pathogenic microorganisms, including Fusobacterium nucleatum, Epstein-Barr virus, Cytomegalovirus, various hepatitis viruses, and coronaviruses, are all related to the occurrence of gastrointestinal cancers.
Non-coding RNAs include miRNA, lncRNA, circRNA, piRNA, etc., which can regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels, through methylation or histone modification, chromatin remodeling, or competitive inhibition. Non-coding RNAs can be used as molecular markers for diagnosis, prognosis prediction, and treatment of digestive system cancers caused by microbial infections. The hot spots in this field include the underlying mechanisms of circRNA, m6A or m5C modification, the interactions between exosome-mediated non-coding RNAs, and the bacterial or viral virulence factors.
This Research Topic welcomes studies on non-coding RNAs as diagnostic and therapeutic biomarkers for gastrointestinal cancers induced by microbial infections and their underlying mechanisms. Aims to elaborate the regulation mechanism of non-coding RNAs in the complex molecular network of gastrointestinal cancers caused by microbial infections and expects to identify some potential biomarkers for the diagnosis, prognosis prediction, and treatments of gastrointestinal cancers caused by microbial infections.
We expect Original Research and Reviews on the diagnosis and treatment of gastrointestinal cancers caused by microbial infections and dysregulation of non-coding RNA. Contributions include but are not limited to the following topics:
• Non-coding RNAs as biomarkers for the diagnosis and prognosis of gastrointestinal cancers caused by microbial infections.
• Research advances on the relationship between non-coding RNAs and the occurrence and progression of gastrointestinal cancers caused by microbial infections.
• Non-coding RNAs as potential therapeutic targets for gastrointestinal cancers caused by microbial infections.
• The relationship between epigenetic modification of non-coding RNA and gastrointestinal cancers caused by microbial infections.
Microbial infections lead to long-term chronic inflammation, repeated DNA damage and repair, metabolic homeostasis disorder and immune system unbalance, which communally contribute to the occurrence of gastrointestinal cancers. It has been well recognized that Helicobacter pylori infection can cause systemic diseases and even cancers, such as gastric cancer, colorectal cancer, and cholangiocarcinoma. Other pathogenic microorganisms, including Fusobacterium nucleatum, Epstein-Barr virus, Cytomegalovirus, various hepatitis viruses, and coronaviruses, are all related to the occurrence of gastrointestinal cancers.
Non-coding RNAs include miRNA, lncRNA, circRNA, piRNA, etc., which can regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels, through methylation or histone modification, chromatin remodeling, or competitive inhibition. Non-coding RNAs can be used as molecular markers for diagnosis, prognosis prediction, and treatment of digestive system cancers caused by microbial infections. The hot spots in this field include the underlying mechanisms of circRNA, m6A or m5C modification, the interactions between exosome-mediated non-coding RNAs, and the bacterial or viral virulence factors.
This Research Topic welcomes studies on non-coding RNAs as diagnostic and therapeutic biomarkers for gastrointestinal cancers induced by microbial infections and their underlying mechanisms. Aims to elaborate the regulation mechanism of non-coding RNAs in the complex molecular network of gastrointestinal cancers caused by microbial infections and expects to identify some potential biomarkers for the diagnosis, prognosis prediction, and treatments of gastrointestinal cancers caused by microbial infections.
We expect Original Research and Reviews on the diagnosis and treatment of gastrointestinal cancers caused by microbial infections and dysregulation of non-coding RNA. Contributions include but are not limited to the following topics:
• Non-coding RNAs as biomarkers for the diagnosis and prognosis of gastrointestinal cancers caused by microbial infections.
• Research advances on the relationship between non-coding RNAs and the occurrence and progression of gastrointestinal cancers caused by microbial infections.
• Non-coding RNAs as potential therapeutic targets for gastrointestinal cancers caused by microbial infections.
• The relationship between epigenetic modification of non-coding RNA and gastrointestinal cancers caused by microbial infections.