The formation of proper neural circuitry relies on an intricate organization of multiple critical events, including cell migration, axon guidance, dendritic growth, synaptic target selection, and synaptogenesis. Pre- and post-synaptic neuronal partners integrally coordinate these events to form functional neural circuits that underlie behaviors. Synaptogenesis marks the final step of this precise temporal and spatial developmental process. It occurs as the post-synaptic neuronal dendrite receives incoming axonal communication at defined sites where synaptic molecules are recruited to establish stable synapses together for both excitatory and inhibitory neurotransmission in functional neural circuits.
Recently, growing evidence indicates that abnormality in neural circuit formation is a likely underlying cause of many congenital disabilities and neurological disorders. Therefore, this aim of this Research Topic is to increase our understanding of the fundamental mechanisms contributing to the critical role of synaptogenesis in both physiological and pathological situations. Currently, significant challenges still persist in improving our understanding of novel molecular mechanisms of synaptogenesis in intrinsic and long-range projections and/or neuromodulatory systems and exploring novel therapeutic approaches in neurological disorders. Therefore, the primary goal of this topic will be to further expand our knowledge about emerging concepts of synaptogenesis in neural circuits, as well as provide insight into fundamental mechanisms of synapse formation and how these processes are perturbed in the pathophysiology of neuronal disorders. This topic welcomes and is not limited to original research, reviews, systematic/mini-reviews, perspectives on:
? The function of novel synaptic transmembrane auxiliary subunits, synaptic molecules, and neuromodulators in glutamatergic/GABAergic synaptogenesis
? Local coordination of glutamatergic/GABAergic inputs in co-regulation of neural circuits
? The molecular pathways involved in normal and pathological synapse formation and synaptic transmission
? Potential synaptogenic therapeutic targets for neuronal disorders include Alzheimer's disease, Huntington’s disease, seizure, insomnia, depression, traumatic brain injury, autism spectrum disorder, obsessive-compulsive and substance abuse disorders etc.
? The function of regional interneurons in synaptogenesis
? The effect of inhibitory or excitatory positive allosteric modulators on synaptogenesis
The formation of proper neural circuitry relies on an intricate organization of multiple critical events, including cell migration, axon guidance, dendritic growth, synaptic target selection, and synaptogenesis. Pre- and post-synaptic neuronal partners integrally coordinate these events to form functional neural circuits that underlie behaviors. Synaptogenesis marks the final step of this precise temporal and spatial developmental process. It occurs as the post-synaptic neuronal dendrite receives incoming axonal communication at defined sites where synaptic molecules are recruited to establish stable synapses together for both excitatory and inhibitory neurotransmission in functional neural circuits.
Recently, growing evidence indicates that abnormality in neural circuit formation is a likely underlying cause of many congenital disabilities and neurological disorders. Therefore, this aim of this Research Topic is to increase our understanding of the fundamental mechanisms contributing to the critical role of synaptogenesis in both physiological and pathological situations. Currently, significant challenges still persist in improving our understanding of novel molecular mechanisms of synaptogenesis in intrinsic and long-range projections and/or neuromodulatory systems and exploring novel therapeutic approaches in neurological disorders. Therefore, the primary goal of this topic will be to further expand our knowledge about emerging concepts of synaptogenesis in neural circuits, as well as provide insight into fundamental mechanisms of synapse formation and how these processes are perturbed in the pathophysiology of neuronal disorders. This topic welcomes and is not limited to original research, reviews, systematic/mini-reviews, perspectives on:
? The function of novel synaptic transmembrane auxiliary subunits, synaptic molecules, and neuromodulators in glutamatergic/GABAergic synaptogenesis
? Local coordination of glutamatergic/GABAergic inputs in co-regulation of neural circuits
? The molecular pathways involved in normal and pathological synapse formation and synaptic transmission
? Potential synaptogenic therapeutic targets for neuronal disorders include Alzheimer's disease, Huntington’s disease, seizure, insomnia, depression, traumatic brain injury, autism spectrum disorder, obsessive-compulsive and substance abuse disorders etc.
? The function of regional interneurons in synaptogenesis
? The effect of inhibitory or excitatory positive allosteric modulators on synaptogenesis